海南地区肝硬化患者胆红素水平与肝纤维化程度相关性分析  

Correlation of serum total bilirubin levels and severity of liver fibrosis in patients with cirrhosis in Hainan province

作　　者：谢建伟[1] 王蔚蔚[1] 艾冬华[1] 

机构地区：[1]中国人民解放军第425医院,海南三亚572008

出　　处：《中国热带医学》2015年第8期987-989,共3页China Tropical Medicine

摘　　要：目的探讨海南地区肝硬化患者血清总胆红素水平与肝纤维化程度相关性。方法选择2013年2月至2014年2月在我院就诊的诊断为肝硬化的患者100例,按照Child-pugh分级标准将全部肝硬化患者分为A级、B级和C级,依次归入A组、B组和C组;同一时期在本科就诊的非肝硬化患者31例为对照组,患者空腹过夜8小时以上,次日抽取静脉血4m L置于非抗凝管中,测定患者血清TBIL,PCⅢ,IV-C,LN,HA水平。结果各组患者LDL,TG,TC水平组间比较差异无统计学意义(P>0.05),A,B,C组患者TBIL,AST,ALT水平均高于对照组,且C组明显高于B组,B组明显高于A组,且差异有统计学意义(P<0.05),A组、B组和C组患者的PCⅢ,IV-C,LN及HA水平均高于对照组,且C组PCⅢ,IV-C,LN及HA水平明显高于B组,B组明显高于A组,差异有统计学意义(P<0.05),患者肝纤维化程度与TBIL有明显相关性(P<0.05),相关系数r为0.393,患者肝纤维化程度与Child-pugh分级有明显相关性(P<0.05),相关系数r为0.594。结论海南地区人体胆红素水平与肝纤维化程度呈正相关。Objective To investigate the correlation of serum total bilirubin levels in cirrhosis patients in Hainan provincea with the severity of liver fibrosis .Methods One hundred cirrhosis patients in 425th Hospital of PLA from February 2013 to February 2014 were schosen and divided into group A, B snd C according to the Child-pugh gading standard, and 31 cases non-cirrhosis inpatient were as control. Patients in each group fasted overnight for a duration of over eight hours and the next day 4mL venous blood was taken from the patients in each group, and the levels of TBIL, PC Ⅲ , IV- C, LN and HA in patients of each group were detected . Results The levels of LDL, TG and TC among the case groups were not statistically significant （P 〉0.05）.The levels of TBIL, AST and ALT in patients of group A, B and C were all higher than that of control group, and the levels of TBIL, AST and ALT in patients of group C was markedly higher than that of group B, group B was higher than that of group A, exhibiting significant difference（P〈0.05）. The levels of PC Ⅲ , IV-C, LN and HA in patients of group A, B and C were all higher than that of control group, the levels of PC m, IV-C, LN and HA in patients of group C were higher than that of group B group was higher than thaqt of group A, revealing significant difference （P〈0.05）.The level of TBIL in patients with liver fibrosis was obviously correlated with the severity of liver fibrosis （P=0.000〈0.05, r = 0.393 ）. The degree of liver fibrosis of patients was correlated with Child-pugh classification （P=0.000〈0.05, r=0.594）. Conclusion The serum level of bilirubin in cirrhosispatients in Hainan was positively correlated with severity of liver fibrosis.

关 键 词：胆红素 肝纤维化 CHILD-PUGH分级 

分 类 号：R657.31[医药卫生—外科学]