骨髓来源细胞治疗放射性唾液腺损伤的研究进展  

Research Progress of Bone Marrow-Derived Cell Therapy for Radiation-Induced Salivary Gland Damage

作　　者：袁瑶薇[1] 袁泽[2] 姜国华[1] 刘宏[3] 刘洋[1] 

机构地区：[1]黑龙江中医药大学基础医学院人体解剖与组织胚胎学教研室,黑龙江哈尔滨150040 [2]哈尔滨医科大学附属第一医院影像科,黑龙江哈尔滨150001 [3]黑龙江中医药大学基础医学院病理学教研室,黑龙江哈尔滨150040

出　　处：《现代生物医学进展》2015年第19期3762-3765,共4页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金面上项目(H201482);黑龙江中医药中青年科技攻关项目;国家自然科学基金青年基金项目(81403288)

摘　　要：罹患头颈部肿瘤的患者在接受放射治疗时往往会发生放射性唾液腺损伤。射线的照射使患者唾液腺结构破坏、功能减退,患者的生活质量严重下降。对于放射性唾液腺损伤,临床上尚无有效的治疗方式。骨髓来源细胞(bone marrow-derived cells,BMDCs)最早用于治疗血液系统疾病。随着对BMDCs认识的逐渐深入,BMDCs的应用领域日益广泛。近些年来,一些动物实验的研究结果表明,利用BMDCs治疗放射性唾液腺损伤能够有效地保护腺体内各种实质细胞,促进腺组织再生,恢复唾液腺功能。本文主要对利用BMDCs治疗放射性唾液腺损伤的治疗方式、治疗效果及其主要的治疗机制进行综述,并对该领域今后的研究方向进行了展望。Radiation therapy for patients with head and neck cancers usually causes radiation-induced salivary gland damage. The radiation destroyed the structures of their salivary glands, and their salivary glands are hypofunction. Therefore, their quality of life is severely reduced. There are no effective treatments for radiation-induced salivary gland damage in clinic. Bone marrow-derived cells （BMDCs） are initially used for hematologic diseases. With a better understanding of BMDCs, the application field of BMDCs is becoming widely. In recent years, the results of some animal experiments showed that BMDC therapy for radiation-induced salivary gland damage could protect the parenchymal cells of salivary glands, promote glandular tissue regeneration and recover the function of salivary glands. This review focuses on that the methods, effects and main mechanisms of BMDC therapy for radiation-induced salivary gland damage, and look forward to the prospective research directions of this field.

关 键 词：骨髓来源细胞 放射性损伤 唾液腺 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学] R730.55[医药卫生—基础医学]