Th17/Treg细胞及其失衡在乙型肝炎致病机制中的作用  

The Role of Th17/Treg Cells and the Imbalance in the Pathogenesis of Hepatitis B

作　　者：饶少锋[1] 冯霞[1] 游晶[1] 段勇[1] 范晶华[1] 张茹薏 

机构地区：[1]昆明医科大学第一附属医院感染性疾病科,云南昆明650032

出　　处：《现代生物医学进展》2015年第19期3773-3776,共4页Progress in Modern Biomedicine

基　　金：云南省科技计划项目(2011WS0053;2011FZ121;2012WS0028)

摘　　要：我国是乙型肝炎病毒(HBV)高感染率国家,乙型肝炎发病机制十分复杂,宿主免疫调节紊乱是导致不能有效清除病毒、病情迁延不愈的重要原因,其中CD4+T淋巴细胞发挥主要作用。最近,新发现的CD4+T细胞的几种亚群为乙型肝炎致病机制的研究提供了新思路。这些新的T细胞亚群中,有一种被称为Th17细胞,表达转录因子ROR-γt,并分泌各种IL-17因子参与免疫反应。另一种为Treg细胞,表达转录因子Fox P3,主要分泌TGF-β因子,当TGF-β单独存在时,初始的效应T细胞分化为Treg细胞。辅助性Th17细胞(Th17)和调节性T细胞(regulatory T cell,Treg)在分化发育、增殖及功能上有着密切的联系,并参与乙型肝炎的致病过程,对乙型肝炎的发生、发展、及愈后有一定影响。最近的研究表明,Th17/Treg的失调可能参与了乙型肝炎的异常免疫反应,从而导致慢性炎症的形成和HBV的持续感染。本文就Th17细胞和Treg细胞及其失衡在乙型肝炎致病机制中的作用予以综述,为乙型肝炎的免疫学治疗提供理论基础。Our country is high-prevalence hepatitis B virus （HBV） country, the pathogenesis of hepatitis B is very complex, host immune adjustment disorder is the main reason of causing ineffectively remove viruses and illness delayed healing, among CD4＋ T lymphocytes playing a major role. Recently, the newly discovered subsets of CD4 ＋ T cell provide a new idea about the pathogenesis of hepatitis B. Among these new T cell subsets, there is a subset known as Th17 cells, which express the transcription factor of ROR-γ and secrete many kinds oflL-17 factors involved in immune response. Another is Treg cells, which express the transcription factor of FoxP3 and can secrete TGF-β factor. When TGF-β is alone, the initial effect oft cell could differentiate into Treg cells. Thl7 cells and Treg cells have closely association between the differentiation proliferation and function. They are both involved in the pathogenic process of hepatitis B, and play a role in the occurrence, development, prognosis of hepatitis B. Recently researches have shown that Thl7/Treg imbalance may be involved in abnormal immune response of hepatitis, resulted in chronic inflammation and persistent infection of hepatitis B. This article briefly reviewed the role of Thl7/Treg and their imbalance in the pathogenesis of hepatitis B, providing a theoretical basis for the immunological treatment of hepatitis B.

关 键 词：辅助性Th17细胞(Th17) 调节性T细胞(Treg) 乙型肝炎 细胞因子 动态平衡 

分 类 号：R512.6[医药卫生—内科学]