苯磺酸氨氯地平在石墨烯修饰玻碳电极上的电分析方法  

Electrochemical determination of amlodipine besylate at graphene modified glassy carbon electrode

作　　者：彭娟[1] 张青春[1] 高作宁[1] 

机构地区：[1]宁夏大学化学化工学院

出　　处：《化学传感器》2015年第2期50-55,共6页Chemical Sensors

基　　金：国家自然科学基金项目(No.21265014)资助

摘　　要：研究了苯磺酸氨氯地平（ADB）在石墨烯（GR）修饰玻碳电极（GR/GCE）上的电化学行为及电化学动力学性质，据此建立了ADB电分析方法。采用电化学阻抗（EIS）法，循环伏安（CV）法，计时电流（CA）法，计时电量法（CC）等测定电极动力学参数。结果表明，ADB在GCE上的直接电化学较迟缓，GR对ADB的电化学氧化具有明显的电催化作用，其氧化峰电流增大了近4倍。用微分脉冲伏安法（DPV）在优化条件下测得氧化峰电流与ADB在6×10-7~1×10-4 mol/L浓度范围内呈良好线性关系，检出限（S/N=3）为8．0×10-8 mol/L。该方法可用于市售ADB药品含量的电化学定量测定。The electrochemical behaviors and electrochemical kinetic of Amlodipine （ADB） at graphene modified glassy carbon electrode （GR/GCE） was studied. The electrochemical quantitative analysis method had been estab-lished. Electrochemical impedance spectroscopy （EIS）,Cyclic voltammetry （CV）;Chronocoulometry （CC）;Chronoam-perometry （CA） and differential pulse voltammetry （DPV） was used to determine the electrode reaction kinetic pa-rameters. The experimental results showed that the electrochemical response on the GR/GCE of ABD is much higher than that on the bare GCE. The oxidation peak current of ADB increased about 4 times compared with that on GCE. Under the optimal conditions, a wide linear of 6.0×10-7 to 1.0×10-4 mol/L was achieved with a detection limit （S/N=3） of 2.4×10-6 mol/L for ADB. This method can be applied in the electrochemical determination of ADB content with simple manipulation with the satisfied results.

关 键 词：苯磺酸氨氯地平 GR修饰电极 电催化氧化 

分 类 号：O657.1[理学—分析化学] R927.2[理学—化学]