帕罗西汀联合小剂量氨磺必利治疗伴有焦虑症状的抑郁症患者的临床研究  

A Comparative Study of the Treatment of Anxiety Symptoms Associated with Depression in Patients with Paroxetine Plus Low-dose Amisulpride

作　　者：黎娟花[1] 胡文生[1] 党亚梅[1] 梅尚英[1] 

机构地区：[1]广州市惠爱医院(原广州市脑科医院),广东广州510060

出　　处：《深圳中西医结合杂志》2015年第12期21-23,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨帕罗西汀联合小剂量氨磺必利治疗伴有焦虑症状的抑郁症患者的疗效与安全。方法:将60例伴焦虑症状的抑郁症患者随机进入单用帕罗西汀组(n=30)或帕罗西汀合并氨磺必利组(n=30)接受为期8周治疗,分别在0、2、4、6、8周末采用《汉密尔顿焦虑量表》(HAMA)及《汉密尔顿抑郁量表-17》(HAMA-17)评定临床疗效,使用TESS量表评定不良反应。结果:两组患者随着治疗的进行,抑郁症状、焦虑症状均有改善,组间比较,差异有统计学意义(P<0.05);两组患者的抑郁症状改善幅度比较,差异无统计学意义(P>0.05);两组患者的焦虑症状改善程度有差异,在治疗4周后治疗组焦虑症状的改善程度明显优于对照组,组间比较,差异有统计学意义(P=0.00)。结论:帕罗西汀联合小剂量氨磺必利能有效产生抗抑郁及抗焦虑作用,起效快,安全性高,依从性好。Objective To investigate the paroxetine in combination with low-dose amisulpride treatment of anxiety symptoms associated with depression in patients with efficacy and safety. Methods 60 patients with anxiety depression were randomized into single paroxetine group（n = 30） or paroxetine with amisulpride group（n=30） receiving treatment for aperiod of eight weeks, respectively, in 0、2、4、6、8 weekend a ＂Hamilton Anxiety Scale＂（hamilton anxiety scale, HAMA） and ＂Hamilton Depression Scale-17＂（HAMA-17） to evaluate the efficacy, using TESS rating scale Adverse reactions. Results Two groups of patients were treated with depressive symptoms, anxiety symptoms were improved between the two groups, the difference was statistically significant（P0.05）; improvement of depressive symptoms in both groups of patients magnitude, the difference was not statistically significant（P 0.05）; there are differences in the degree of improvement in anxiety symptoms in both groups of patients, the degree of improvement in the treatment of anxiety symptoms after 4 weeks of treatment was significantly better than the control group between the two groups, the difference was statistically significant（P=0.00）. Conclusions Paroxetine plus low-dose amisulpride is effective to produce antidepressant and anxiolytic effects, rapid onset, high security and better compliance.

关 键 词：伴焦虑症状的抑郁症 帕罗西汀 氨磺必利 

分 类 号：R749[医药卫生—神经病学与精神病学]