Th1/Th2失衡与缺血/再灌注损伤及中药多靶点调节的应用前景分析  

Th1 / Th2 imbalance in ischemia-reperfusion injury and the application prospects of traditional Chinese medicine with multi-target effect

作　　者：邓雪红[1] 邢小燕[1] 李光[1,2] 张美双[1,3] 石金金[1,4] 孙桂波[1] 孙晓波[1] 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,北京100193 [2]中国医学科学院药用植物研究所云南分所,云南景洪666100 [3]长春中医药大学,吉林长春130117 [4]郑州大学药学院,河南郑州450001

出　　处：《中国药理学通报》2015年第9期1185-1189,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81303257;81374011;81374010);中国博士后科学基金资助项目(No 2013M540067;2014T70054)

摘　　要：缺血组织恢复血流后,组织损伤程度急剧增加,免疫反应是缺血/再灌注造成组织二次损伤的关键因素之一。Th1/Th2在正常机体中处于免疫平衡状态,在缺血/再灌注环境下,易发生Th1/Th2漂移,形成Th1优势状态,介导细胞免疫。过度的免疫反应即可引起细胞凋亡和组织损伤。研究发现,诱导Th1优势状态向Th2优势状态转化,是治疗缺血/再灌注损伤的可行途径。随着多组分、多靶点的现代药物研发模式的兴起,中药在治疗复杂疾病中的优势凸显。该文从Th1/Th2失衡与缺血/再灌注损伤关系及中药在该疾病中的应用前景进行了综述。The damage of tissue increases dramatically after reperfusion of blood supply to ischemic tissues. Immune response is one of the key reasons of ischemia-reperfusion injury. Th1 /Th2 generally stays balanced in normal states. Under the environment of ischemia reperfusion,Th1 / Th2 shifting let Th1 dominant to mediate cellular immunity. Excessive immune reaction may cause cell apoptosis and tissue damage. Recent studies showed that induction of transferring Th1 dominant to Th2 dominant was feasible for the treatment of ischemia-reperfusion injury. With the progress of modern drug development paradigm＂multi-composition,multi-target＂,Chinese medicine has advantages in treating complex diseases. This paper summarizes the research of the relationship between Th1 / Th2 imbalance and ischemia-reperfusion injury,together with the prospects of traditional Chinese medicine with multi-target effect in ischemiareperfusion injury.

关 键 词：缺血/再灌注损伤 辅助性T细胞 TH1/TH2 免疫反应 中药 多靶点 

分 类 号：R282.71[医药卫生—中药学] R329.24[医药卫生—中医学]