预防使用抗菌药物对冠状动脉支架置入术后感染的影响  

Effects of Prophylactic Antibiotics on Infections after Coronary Stent Implantation

作　　者：李晶晶[1] 武欣迎[2] 徐隽[1] 杜丽芬[1] 宋红萍[1] 陈冠容[1] 顾晔[2] 

机构地区：[1]华中科技大学同济医学院附属普爱医院药剂科,武汉430033 [2]华中科技大学同济医学院附属普爱医院心内科,武汉430033

出　　处：《医药导报》2015年第9期1227-1230,共4页Herald of Medicine

基　　金：武汉市卫生和计划生育委员会科研项目(WX12C32)

摘　　要：目的探讨冠状动脉支架置入术患者是否需要常规预防使用抗菌药物。方法回顾性分析2010年1月—12月156例(使用预防性抗菌药物组)和2014年1月—12月466例(未使用预防性抗菌药物组)冠状动脉支架置入术的临床资料,对比分析两组术后感染发生率。结果未使用和使用预防性抗菌药物组与支架植入术相关的感染如手术部位感染发生率分别为0.2%,1.3%(P>0.05);血管相关性感染发生率分别为0.6%,1.9%(P>0.05),以及与手术无直接相关的感染发生率差异无统计学意义(P>0.05)。结论冠状动脉支架置入术患者无需常规预防性使用抗感染药物。Objective To analyze whether routine prophyrlactic antibiotic administration is necessary for the patients undergoing coronary stent implantation. Methods The clinical data of 156 patients from January 2010 to December 2010( prophylactic antibiotic therapy),and 466 patients from January 2014 to December 2014( no-prophylactic antibiotic therapy),who underwent coronary stent implantation,were retrospectively analyzed. The infection rates in two groups were compared.Results The rate of infections related to coronary stent implantation in no-prophylactic antibiotic therapy group and prophylactic antibiotic therapy group,such as surgical site infection( 0.2% vs 1.3%,P>0.05) and catheter-related infection( 0.6% vs 1.9%,P>0.05),was not significant different( P > 0. 05). Similarly,the unrelated to coronary stent implantation was not significant different,too( P>0.05). Conclusion Routine prophylactic antibiotic administration is unnecessary for the patients undergoing coronary stent implantation.

关 键 词：抗菌药物 预防使用 冠状动脉支架置入术 感染 

分 类 号：R978.1[医药卫生—药品]