妥洛特罗贴剂联合布地奈德雾化治疗小儿慢性咳嗽的疗效及其机制研究  

Efficacy and mechanism of tulobuterol tape combined with budesonide atomization inhalation in treatment for children chronic cough

作　　者：徐凯虹[1] 周罗根[1] 

机构地区：[1]南京医科大学附属常州第二人民医院儿科,江苏南京213003

出　　处：《临床和实验医学杂志》2015年第17期1474-1476,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨妥洛特罗贴剂联合布地奈德雾化治疗小儿慢性咳嗽的疗效及其作用机制。方法选取60例慢性咳嗽患儿,随机分为观察组和对照组,每组30例。对照组仅给予布地奈德雾化治疗,观察组采用妥洛特罗贴剂联合布地奈德雾化治疗。比较两组患者临床疗效、咳嗽症状评分及外周血炎症指标。结果治疗后,观察组患儿咳嗽症状评分显著低于对照组(0.54±0.28 vs.1.16±0.26),差异具有统计学意义(t=2.853,P<0.05)。观察组临床总有效率显著优于对照组(93.3%vs.73.3%),差异具有统计学意义(χ2=4.320,P<0.05)。观察组患儿外周血嗜酸性粒细胞(Eos)计数、肿瘤坏死因子-α(TNF-α)、白介素-5(IL-5)均明显低于对照组,差异具有统计学意义(P<0.05)。结论妥洛特罗贴剂联合布地奈德雾化吸入小儿慢性咳嗽,与单用地奈德雾化吸入治疗相比较,临床疗效更优,其作用机制可能是通过有效抑制炎症细胞、炎症因子及介质的释放来发挥协同作用。Objective To evaluate the efficacy and mechanism of tulobuterol tape combined with budesonide atomization inhalation in treatment for children chronic cough. Methods 60 children of chronic cough were randomly divided into control group and observation group,30 cases in each group. Tulobuterol tape combined with budesonide atomization inhalation were used in observation group and budesonide atomization inhalation alone was used in control group. The clinical efficacy,cough symptom scores and peripheral inflammation index were compared between the two groups. Results After treatment,the cough symptom scores in observation group and control group respectively was(0. 54 ± 0. 28)points and(1. 16 ± 0. 26)points. The points of observation group was significantly lower than control group,showed significant differences between the two groups( t =2. 853,P <0. 05). The clinical efficacy was 93. 3% in observation group,as compared with those of 73. 3% in control group, which showed significant differences between the two groups(χ2 =4. 320,P <0. 05). The ECP,Eos,TNF-αand IL-5 of peripheral blood in observation group was lower than those in control group( P <0. 05). Conclusion Tulobuterol patch budesonide inhalation as the treatment of chronic cough in children showed clinical better efficacy compared to budesonide inhalation therapy. And its mechanism may be effectively sup-pressed by inflammatory cells,inflammatory cytokines and media releasing of synergies.

关 键 词：小儿 慢性咳嗽 妥洛特罗 布地奈德 

分 类 号：R725.6[医药卫生—儿科]