SIRT1基因的表达调控及对动物脂类代谢的功能  

Expression Regulation and Functions of Lipid Metabolism of SIRT1 Gene

作　　者：邵芳[1] 郁建锋[2] 张燕萍[2] 顾志良[2] 

机构地区：[1]南京医科大学附属常州第二人民医院肿瘤研究所,江苏常州213003 [2]常熟理工学院生物与食品工程学院,江苏常熟215500

出　　处：《常熟理工学院学报》2015年第4期8-14,共7页Journal of Changshu Institute of Technology

基　　金：国家自然科学基金"鸡SIRT1基因的表达调控及其对肝脏脂类代谢的功能研究"(31472091);江苏省自然科学基金"MicroRNA调控鸡SIRT1基因表达的分子机理研究"(SBK2015021516);苏州市产业技术创新专项(应用基础研究-农业)项目"MicroRNA调控鸡SIRT1基因表达的研究"(SYN201516)

摘　　要：SIRT1是Sirtuin家族的一个成员,一种NAD+-依赖性蛋白去乙酰化酶.SIRT1通过与p53、Ku70、FOXOs、PGC-1A、p300和H1、H3、H4等不同的非组蛋白和组蛋白相互作用来发挥不同的功能.SIRT1基因调控肝脏、脂肪、肌肉、胰岛和脑等器官中的糖脂代谢.SIRT1是脂类稳态的一个重要调节因子,并且对脂肪酸的氧化也起作用.SIRT1自身的表达和活性在转录水平、转录后水平及翻译后水平都受到调控.本文综述SIRT1基因的表达调控及对动物脂类代谢的功能.SIRT1, a member of the Sirtuin family, is a kind of NAD＋-dependent histone deacetylase. SIRT1 interacts with non-histone proteins and histone such as p53, Ku70, FOXOs, PGC-1A, p300 as well as H1, H3, H4 to exert different functions. SIRT1 gene performs the regulation of glucose and lipid metabolism in the liver, fat, muscle, pancreatic and brain and other organs. SIRT1 is an important regulator of lipid homeostasis factor, and also plays a role in the oxidation of fatty acids. Expression and activity of SIRT1 will be regulated at a tran- scriptional, post-transcriptional and post-translational level respectively, and gene expression regulation and roles for lipid metabolism of sirtl in animals will be reviewed in this paper.

关 键 词：Sirtuin家族 SIRT1基因 脂类代谢 表达调控 

分 类 号：Q493[生物学—生理学] Q75