药对研究(Ⅲ)——葛根人参药对对大鼠肠吸收的影响  

Traditional Chinese medicine pairs( Ⅲ) —effect of extract of Ginseng Radix et Rhizoma and Puerariae Lobatae Radix on intestinal absorption in rats

作　　者：陈益杭 李孟璇[1] 孟兆青[1,2] 杨姣姣[2] 黄文哲[1] 王振中[1] 王跃生[1,3] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司,江苏连云港222001 [2]中国药科大学,江苏南京210009 [3]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2015年第15期3094-3099,共6页China Journal of Chinese Materia Medica

摘　　要：为研究药对配伍的科学内涵,该研究从药物的肠吸收角度出发,通过大鼠在体单向肠灌流实验比较葛根单提、人参单提、葛根人参合提、葛根人参合并4组药物在大鼠体内的吸收情况。用HPLC测定了药液中指标成分葛根素、人参皂苷Rg1、人参皂苷Rb1、人参皂苷Re的含量。计算并比较速率常数(Ka)与表观吸收系数(Papp)。其中葛根素的Ka和Papp依次为葛根人参合并组>葛根单提组>葛根人参合提组。人参皂苷Rg1,Re,Rb1的Ka和Papp依次为葛根人参合并组>人参单提组>葛根人参合提组。葛根、人参合并给药可能提高药物在消化道内的吸收。This study focused on the intestinal absorption of traditional Chinese medicines（ TCM） to reveal the scientific connotation of the compatibility of TCM pairs. The single pass intestinal perfusion（ SPIP） was used in rats to compare the absorption of single extracts from Puerariae Lobatae Radix,single extracts from Ginseng Radix et Rhizoma,combined extracts from Puerariae Lobatae Radix and Ginseng Radix et Rhizoma and Puerariae Lobatae Radix and Ginseng Radix et Rhizoma mixture in rats. The content of puerarin,ginsenoside Rg1,ginsenoside Re and ginsenoside Rb1 in liquid were tested by HPLC. The speed constant（ Ka） and apparent permeability coefficients（ Papp） were calculated and compared. Specifically,the order of puerarin Kaand Pappvalues from high to low was Ginseng Radix et Rhizoma and Puerariae Lobatae Radix mixture single extracts from Puerariae Lobatae Radix combined extracts from Ginseng Radix et Rhizoma and Puerariae Lobatae Radix; the order of ginsenosides Kaand Pappvalues from high to low was Ginseng Radix et Rhizoma and Puerariae Lobatae Radix mixture single extracts from Ginseng Radix et Rhizoma combined extracts from Ginseng Radix et Rhizoma and Puerariae Lobatae Radix. The combined administration of Ginseng Radix et Rhizoma and Puerariae Lobatae Radix may improve the absorption in the intestinal tract.

关 键 词：葛根 人参 单向肠灌流 

分 类 号：R285.5[医药卫生—中药学]