防御素调节腹盆腔放疗肠道微生态失调的研究进展  

Expression of defensins and microecological imbalance in abdominal orpelvic radiotherapy:research progress

作　　者：冉曦[1] 龙爽[2] 冉新泽[2] 王艾平[1] 

机构地区：[1]第三军医大学军事预防医学院全军复合伤研究所,重庆400038 [2]第三军医大学创伤烧伤与复合伤国家重点实验室,重庆400038

出　　处：《中国微生态学杂志》2015年第8期976-979,共4页Chinese Journal of Microecology

基　　金：国家自然科学基金(81172600)

摘　　要：防御素作为内源性的抑菌/杀菌剂对胃肠道菌群平衡有重要作用,还可用来改善肠内菌群生态失调。放疗在杀伤癌细胞同时对正常细胞有较大影响,影响肠道屏障和肠内菌群平衡。而防御素有协同抗微生物活性和免疫应答作用,可改善腹盆腔放疗后胃肠道微生态失调。本研究对防御素、肠道微生态、腹盆腔放疗后防御素与微生态失调以及防御素对腹盆腔治疗的影响等做一综述。Defensins,as a kind of endogenous antibiotics with broad microbicidal activity,play an important role in maintaining gut microecological environment and have been employed to ameliorate intestinal microflora dysbiosis.Radiotherapy nonspecifically kills tumor cells and normal cells,leading to intestinal barrier dysfunction and imbalance of intestinal microflora.Endowed with antimicrobial activity and ability to regulate immune response,defensins could ameliorate radiotherapy-associated dybiosis by shaping the compositions of the colonized microbiota.This review focused on recent research progress on defensins,intestinal microflora,potential therapeutic role of defensins in remedying micro-ecological imbalance after abdominal or pelvic radiotherapy.

关 键 词：防御素 微生态失调 肠道菌群 肿瘤 放疗 

分 类 号：R372[医药卫生—病原生物学]