Tim-3在急性冠状动脉综合征患者的表达及其临床意义  

Expression of Tim-3 in patients with acute coronary syndrome and its clinical significance

作　　者：余天浩[1] 李瑜辉[1] 陈武奇[1] 谢佳佳[1] 伍灏堃 张婷婷[1] 

机构地区：[1]广东省第二人民医院心血管内一科,广州510317

出　　处：《中华生物医学工程杂志》2015年第2期149-152,共4页Chinese Journal of Biomedical Engineering

基　　金：广东省医学科学技术研究基金（B2012052）

摘　　要：目的：研究Tim-3在急性冠状动脉综合征患者中的表达及其临床意义。方法选取广东省第二人民医院心血管内科病房2012年1月至2013年1月住院治疗的临床病例，分为对照组（48例）和急性冠状动脉综合征组（133例）。检测研究外周血各细胞亚群上及外周血单个核细胞上Tim-3的表达与TG、LDL-C、CRP、IL-6及TNF-a的血清水平及相关关系。结果 Tim-3外周血CD14＋单核细胞组成性高表达Tim-3，且明显高于对照组（P〈0.05）。患者血清学炎症指标CRP和TNF-a较健康对照显著升高。单核细胞Tim-3的表达与TG、IL-6、TNF-a、CRP都与单核细胞上Tim-3的表达水平正相关。结论单核细胞表达的Tim-3与ACS患者体内炎症密切相关。Objective To investigate Tim-3 expression in patients with acute coronary syndrome （ACS） and its clinical significance. Methods Patients hospitalized and treated in the Department of Cardiology, Second People’s Provincial Hospital of Guangdong between January 2012 and January 2013 were included in the study, and were divided into the control group （n=48） and the ACS group （n=133）. The expression of Tim-3 and its correlation with the serum levels of TG, LDL-C, CRP, IL-6 and TNF-α in each cell subset and mononuclear cell of peripheral blood were determined. Results The constitutive high expression of Tim-3 was found in peripheral blood CD14＋mononuclear cells and was significantly higher than that in the control group （P〈0.05）. Compared with the healthy controls, the serological inflammatory indexes, including CRP and TNF-α, significantly increased in patients. The expression of Tim-3 in mononuclear cells were positively correlated with TG, IL-6, TNF-αand CRP the expression level of Tim-3 in mononuclear cells. Conclusion The expression of Tim-3 in mononuclear cells is closely related to inflammation in the body of the patients with ACS.

关 键 词：急性冠状动脉综合症 TIM-3 动脉粥样硬化 炎症反应 TIM-3 

分 类 号：R543.3[医药卫生—心血管疾病]