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机构地区:[1]苏州大学(中国人民解放军第二炮兵总医院研究生培养基地),北京100088 [2]中国人民解放军第二炮兵总医院泌尿外科
出 处:《中国男科学杂志》2015年第6期48-53,58,共7页Chinese Journal of Andrology
摘 要:目的 利用Meta分析观察复方玄驹胶囊治疗不育症的疗效.方法 检索Cochrane图书馆,Pubmed数据库,中国生物医学文献数据库,CNKI数据库,VIP数据库,万方数据库,纳入复方玄驹胶囊治疗不育症的随机对照治疗(RCT),并进行方法学质量评价,采用RevMan5.3软件进行统计分析,并发表偏倚评估和敏感性分析.结果 9篇RCT文献纳入本项研究,累计病例1199例.Meta分析结果显示:复方玄驹胶囊在改善和提高A级精子率[WMD=1.35,95%CI(-6.36,9.07),P=0.73]、(a+b)级精子率[WMD=6.54,95%CI(-17.03,30.11),P=0.59]、精子密度[WMD=3.80,95%CI(-4.23,11.82),P=0.35]、精子活率[WMD=-68.66,95%CI (-12.13,-5.19),P<0.01]、显效率[RR=0.79,95%CI (0.51,1.23),P=0.30]和总有效率[RR=0.86,95%CI (0.70,1.05),P=0.13]方面并无优势,而在改善正常形态百分率[WMD=9.00,95%CI (0.59,17.40),P=0.04]方面优于对照组.结论 复方玄驹胶囊可更有效改善精子正常形态百分率,是治疗男性不育症的有效药物,但尚需进一步的大样本、高质量、多中心的随机对照的双盲临床试验.Objective To explore the effects of the Chinese medicine Fufang Xuanju capsule on Oligospermia and asthenospermia using Meta-analysis. Methods Randomized controlled trials (RCTs) related to Fufang Xuanju capsue for treatment of oligospermia and asthenospermia were collected from the database, such as the Cochrane Library, Pubmed, CBMdisc, CNKI, VIP and Wangfang. After the necessary methodological quality evaluation of publication bias and sensitivity analysis of the selected studies, the statics analysis was conducted by the software RevMan5.3 Results Nine eligible reports were identified for Meta-analysis, including 1199 cases. The Meta-analysis results showed that no significances were found for Fufang Xuanju capsule to improve the grade A sperm rate [WMD=l.35,95%CI(-6.36, 9.07), P=0.73], the grade A+B sperm rate [WMD=6.54,95%CI(-17.03, 30.11), P=0.59], the sperm density [WMD--3.80,95%CI(-4.23, 11.82), P=0.35], the sperm motility[WMD=-68.66, 95%CI(- 12.13, -5.19), P〈0.01 ] , obvious effect rate [RR= 0.79,95%CI(0.51, 1.23), P=0.30]and the total effective rate[RR= 0.86,95%CI(0.70, 1.05), P=0.13], whereas a significance was found for Fufang Xuanju capsule to improve percentage of normal sperm morphology[WMD=9.00,95%CI(0.59, 17.40),P=0.04]. Conclusion The Chinese medicineFufangXuanju capsule did show definite curative effect in the treatment of oligospermia and asthenospermia, which need more large-scale,high quality, multi-centre, randomized, double-blind, parallel-controlled trials for further investigation.
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