不同剂量右美托咪啶复合丙泊酚对高血压患者腹部手术麻醉效果的影响  

Anesthetic Effect Study of Different Doses of Dexmedetomidine and Propofol on Hypertensive Patients with Abdominal Operation

作　　者：欧阳文博[1] 卢先卿[1] 余镇佳 何惠娇[1] 冯秀芬[1] 

机构地区：[1]肇庆市第一人民医院,广东肇庆526060

出　　处：《深圳中西医结合杂志》2015年第14期32-34,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:观察不同剂量右美托咪啶复合丙泊酚对高血压患者行腹部手术麻醉效果的影响。方法:选取2012年1月-2013年6月于我院行腹部麻醉手术高血压者180例,以数字法随机分为A、B组和对照组,各60例。A组持续注射高剂量右美托咪啶,B组注射低剂量右美托咪啶,对照组加用相同容量的0.9%氯化钠注射液。结果:在T1、T2、T3时刻A、B组心率(HR)、收缩压(SBP)以及舒张压(DBP)水平均低于对照组,差异有统计学意义(P<0.05),A、B组在对血流动力学的稳定效果优于对照组;A、B组自主呼吸恢复时间、苏醒时间、拔除气管导管时间、定向力恢复时间少于对照组,(P<0.05)。A组不良反应总例数低于B组(P<0.05)。结论:右美托咪啶复合丙泊酚对高血压患者麻醉效果较好,高剂量右美托咪啶对抑制麻醉苏醒后的过激反应效果更显著,手术不良反应发生率也更低,总体效果更好。Objective To study the anesthesia effects of different doses of dexmedetomidine and propofol on hypertensive patients with abdominal operation. Methods 180 cases of high blood pressure were randomly divided into A and B group and the control group（n = 60）. 60 cases in each group Continuous injection of high dose dexmedetomidine for group A and injection of low dose Propofol for group B, add the same volume of physiological saline to control group. Results A, B group can obviously reduce the hemodynamic response, and A slightly better than B group. A and B group at a time and the dosage of propofol anesthesia on less than the control group, and each index comparison, surgical adverse reactions in anesthesia cases were better than that of control group（P〈0.05）. Adverse effects on the total number of cases of group A is lower than group B（P〈0.05）. Conclusion Application effect of dexmedetomidine and propofol on patients with high blood pressure is good. High dose dexmedetomidine has more significant effect, and the operation and lower incidence of adverse reactions, the overall effect is better.

关 键 词：高血压 右美托咪啶 丙泊酚 麻醉 药物剂量 

分 类 号：R656[医药卫生—外科学] R544.1[医药卫生—临床医学]