聚砜中空纤维膜式人工肺的等离子体改性研究  

Research on plasma modification of polysulfone hollow fiber membrane for artificial lung

作　　者：刘耀东[1] 黄鑫[1] 王伟平[1] 虞文魁[2] 李磊[1] 

机构地区：[1]南京大学化学化工学院,南京210093 [2]南京大学医学院,南京210093

出　　处：《膜科学与技术》2015年第4期35-39,共5页Membrane Science and Technology

基　　金：江苏省自然科学基金面上项目(BK2012727)

摘　　要：利用低温等离子体技术在用于膜式人工肺的聚砜(PSf)中空纤维膜表面接枝丙烯酸(AA)和肝素,通过改性以提高膜材料的血液相容性.通过改性前后膜的接触角及接枝率测试结果比较,得出优化的改性条件,即选用氩气(Ar)作为等离子体气源,处理功率为40 W及处理时间为60s.改性后膜材料对牛血清白蛋白(BSA)及血小板黏附量显著减少.此外模拟人工肺进行气液双侧传输测试的结果表明,改性后膜材料保持了初始膜优良的气体传输性能,基本符合常见临床膜式人工肺标准.Acrylic acid （AA） and heparin were grafted onto the surface of PSf hollow fiber membranes for artificial lung by low temperature plasma technology to improve their blood compatibility. The contact angle and grafting degree of modified PSf membrane was optimized by being treated for process time of 60s with Argon（At） atmosphere at power of 40 W. The amounts of adsorbed BSA and adhesive platelets on the grafted PSf membranes decreased significantly. Besides, the experimental results of gas- liquid transfer indicated that the modified membrane retained excellent gas permeation flux of PSf membrane, which could achieve basically the gas exchange transmission capacity of artificial lung.

关 键 词：聚砜中空纤维膜 人工肺 等离子体改性 肝素钠 血液相容性 

分 类 号：TQ051.893[化学工程]