吸毒男性梅毒感染者CD4^+CD25^+调节性T细胞表达及影响因素分析  

An analysis on the expression level and influencing factors of CD4^+CD25^+ regulatory cells among male drug-abusers with syphilis

作　　者：丛迎[1] 陈秀英[1] 周颖[2] 雷永良[1] 刘敏[1] 叶灵[1] 陈沙彬[1] 

机构地区：[1]丽水市疾病预防控制中心,浙江丽水323000 [2]丽水市人民医院

出　　处：《浙江预防医学》2015年第9期865-868,共4页Zhejiang Journal of Preventive Medicine

摘　　要：目的探讨吸毒男性梅毒感染者CD4+CD25+调节性T细胞表达情况及其影响因素。方法测定144例吸毒男性梅毒感染者、41例吸毒男性非梅毒感染者、35例男性单纯梅毒感染者和35名健康男性的CD4+CD25+调节性T细胞(Treg)表达水平,并问卷调查梅毒感染吸毒者的吸毒年限、吸毒类型和吸毒方式。结果吸毒梅毒组CD4+CD25+Treg水平均高于吸毒非梅毒组和非吸毒梅毒组(P<0.01)。在不同期梅毒、不同吸毒类型和不同吸食方式患者中,吸毒年限>1年者CD4+CD25+Treg水平均高于≤1年者(P<0.01),患者CD4+CD25+Treg水平与吸毒年限呈正相关(R2=0.672,P<0.01)。吸毒患者中,传统与新型毒品均吸食者CD4+CD25+Treg水平高于单一的吸食传统食品或新型毒品者(P<0.01)。注射与非注射吸毒者CD4+CD25+Treg水平高于采用注射或非注射一种吸毒方式者,差异均有统计学意义(P均<0.01)。吸毒年限>1年者中,吸食传统毒品者和注射吸毒者CD4+CD25+Treg水平分别高于吸食新型毒品者和非注射吸毒者(P均<0.01)。结论吸毒男性梅毒感染者CD4+CD25+Treg表达增高可能导致的细胞免疫功能抑制与吸毒年限有关,并受毒品类型和吸毒方式影响。Objective To explore the expression level and influencing factors of CD4 +CD25 + regulatory cells(Treg)among male drug -abusers with syphilis.Methods 144 male drug -abusers with syphilis,41 male drug -abusers without syphilis,35 male non -drug abuser with syphilis and 35 male healthy volunteers were enrolled in this study.Expression levels of CD4 +CD25 +Treg of them were detected.A questionnaire interview was conducted among these participants, including drug abuse duration,drug types and abuse ways.Results The levels of Treg expression of drug -abusers with syphilis were significantly higher than that of drug -abusers without syphilis and non -drug abuser with syphilis (P <0.01 ).Despite of the stage of syphilis,types of drugs and abuse way,Treg expression levels with drug abuse duration of"above 1 -year"were significantly higher than those of "1 -year or below"(P <0.01 ).Treg expression levels were positively correlated to drug abuse duration (R2 =0.672,P <0.01)among patients.Among the participants,people both with traditional and new drugs were significantly higher than that with only traditional or new drug (P <0.01).In addition, people both with injecting and non -injecting abuse were significantly higher than that with one way of drug -abuse (P <0.01).Among those with drug abuse duration of "above 1 -year",Treg levels of drug -abusers with traditional drugs and injecting abuse way were remarkably higher than that with new drug and non -injecting abuse respectively (P <0.01). Conclusion Among male drug -abusers with syphilis,suppression of cellular immune function resulting from increased CD4 +CD25 +regulatory T cells is related to drug abuse duration,and is also influenced by drug types and abuse ways.

关 键 词：梅毒感染 吸毒 CD4^+CD25^+调节性T细胞 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]