舒张性心力衰竭患者血清糖类抗原125与脑钠肽前体、左心室结构及心功能的相关性分析  

Correlation analysis of serum CA125 and B-type natriuretic peptide precursor, left ventricular structure and function in patients with diastolic heart failure

作　　者：罗仪山 潘宜智[2] 

机构地区：[1]广州医科大学研究生院,广州510182 [2]广州市第一人民医院心血管内科,广州510180

出　　处：《岭南心血管病杂志》2015年第4期459-461,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的研究舒张性心力衰竭(diastolic heart failure,DHF)患者血清糖类抗原125(carbohydrate antigen 125,CA125)与脑钠肽前体(B-type natriuretic peptide precursor,pro-BNP)、左心室结构及心功能的关系。方法 135例DHF患者根据纽约心脏协会(NYHA)心功能分级标准分为Ⅰ级、Ⅱ级、Ⅲ/Ⅳ级共3组,比较各组血清CA125浓度,分析血清CA125浓度与血清pro BNP浓度、左心室射血分数、左心室大小、左心室舒张末内径、左心室收缩末内径的相关性。结果血清CA125浓度随纽约心脏协会心功能分级增高而增高。血清CA125浓度与血清pro-BNP浓度(r=0.512,P<0.01)、左心室(r=0.360,P<0.01)、左心室收缩末内径(r=0.388,P<0.01)、左心室舒张末内径(r=0.337,P<0.01)呈正相关关系,与左心室射血分数(r=-0.396,P<0.01)呈负相关关系。结论 DHF患者血清CA125浓度与心力衰竭的严重程度及心室重构相关,可能是诊断和评价DHF的又一个指标。Objectives To study the relationships of serum CA125 and B-type natriuretic peptide precursor（proBNP）, left ventricular structure and cardiac function in patients with diastolic heart failure（DHF）. Methods Totally135 patients with DHF were divided into 3 groups as grade Ⅰ group, grade Ⅱ group, and grade Ⅲ / Ⅳ group according to New York Heart Association（NYHA）classification. Serum concentrations of CA125 in all the patients were measured.Correlations of serum CA125 and pro-BNP, left ventricular ejection fraction（LVEF）, left ventricle（LV） size, left ventricular end-diastolic diameter（LVDD）, left ventricular end-systolic diameter（LVSD） were compared among the three groups. Results Serum concentration of CA125 increased as NYHA class increased. Serum concentration of CA125 positively correlated with pro-BNP（r=0.512, P〈0.01）, LV size（r=0.360, P〈0.01）, LVSD（r=0.388,P〈0.01）,LVDD（r =0.337,P〈0.01）, and negatively correlated with LVEF（r =-0.396,P〈0.01）. Conclusions Serum concentration of CA125 is associated with the severity of DHF and ventricular remodeling. It may be a good indicator of diagnosis and evaluation of DHF.

关 键 词：心力衰竭 糖类抗原125 B型钠尿肽前体 心室重构 

分 类 号：R541.6[医药卫生—心血管疾病]