19530例泌尿生殖道感染患者支原体感染及药敏结果分析  

Analysis on the infection and drug susceptibility of mycoplasma in 19530 cases of urogenital tract infections

作　　者：龚娅[1] 段德令 何宗忠[1] 王晓冬[1] 史秋霞[1] 林林东[1] 欧炜华[1] 

机构地区：[1]广州军区广州总医院157分院检验科,广州510510

出　　处：《重庆医学》2015年第25期3539-3541,共3页Chongqing medicine

摘　　要：目的分析该地区泌尿生殖道支原体感染及耐药状况，为临床合理用药提供依据。方法采用支原体培养、鉴定、药敏试剂盒对19530例泌尿生殖道感染患者的送检标本进行检测，分析支原体感染及药敏情况。结果19530例送检样本中，支原体阳性11178例，阳性率为57．24％，其中解脲支原体（Uu）、人型支原体（Mh）、Uu＋Mh混合感染阳性率分别为44．63％、0．44％和12．17％；女性支原体阳性率高于男性，差异有统计学意义（P〈0．05）；2008～2014年支原体阳性率呈上升趋势；支原体对交沙霉素、强力霉素、米诺环素、克拉霉素敏感率分别为88．57％、84．32％、76．09％、71．53％，对喹诺酮类抗茵药物耐药率高；Uu、Mh和Uu＋Mh3类感染对12种抗菌药物的耐药种数递增。结论泌尿生殖道感染以Uu感染为主，Mh感染多以混合感染方式出现；交沙霉素、强力霉素是该地区治疗支原体的首选药物，临床可参考药敏结果合理用药。支原体多重耐药情况严重，应引起临床重视。Objective To analyze the status of mycoplasma infection and drug resistance in the local area,and provide the basis for clinical rational drug use. Methods The specimens obtained from 19 530 patients with urogenital tract infection were detected by adopting mycoplasma culture,identification and drug sensitivity integration kit. Mycoplasma infection and drug susceptibility were analyzed. Results In the total of 19 530 susPected patients specimens, 11 178 cases were positive with a positive rate 57.24%. The positive rate of ureaplasma urealyticum （Uu） and mycoplasma hominis （MH） was 44.63 % and 0.44% respectively and the positive rate of Uu and Mh mixed infection was 12.17%. The positive rate of female was higher than that of male and the difference was statistically significant（P〈0.05）. The positive rate of mycoplasma in 2008--2014 was on the rise;The sensitive rate of mycoplasma to josamycin, doxycycline, minocycline element, clarithromycin was 88.57%, 84.32 %, 76.09% and 71.53% respectively,mycoplasma was highly drug resistance to quinolone antibiotics;mixed infection resistance was higher than that of single infection;The number of drug resistance of Uu,MH and Uu＋MH to 12 kinds of antibiotics increase. Conclusion Mycoplasma infection in urogenital tract is mainly caused by Uu and Mh infection is in mixed infection way;josamycin,doxycycline is the first choice for treatment of mycoplasma in this region. Rational drug choise can be based on the drug susceptibility test. Multiple drug resistance of mycoplasma is serious and should be paid attention to.

关 键 词：支原体 泌尿生殖道 药敏试验 耐药率 多重耐药 

分 类 号：R446.5[医药卫生—诊断学]