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机构地区:[1]辽宁医学院,辽宁锦州121000 [2]辽宁医学院附属第一医院,辽宁锦州121000
出 处:《解放军医学院学报》2015年第8期840-844,共5页Academic Journal of Chinese PLA Medical School
基 金:辽宁省科技厅科技攻关计划(2013225305)~~
摘 要:目的通过紫外-可见分光光度法测定魟鱼软骨多糖滴眼液在家兔眼内角膜、虹膜、玻璃体及房水的药物浓度并进行药代动力学的研究。方法将20只家兔随机分成10组,每组2只,对兔眼给药处理后在10 min、20 min、30 min、60min、90 min、120 min、180 min、240 min、300 min、360 min 10个不同时间点迅速地剥离出角膜与虹膜并抽取房水收集玻璃体,通过紫外-可见分光光度计测定10个不同时间点眼内角膜、虹膜、玻璃体及房水内的魟鱼软骨多糖的药物浓度,并进一步计算药代动力学参数。结果魟鱼软骨多糖滴眼液在兔眼角膜、虹膜、玻璃体及房水中的线性回归方程分别为Y=0.029 1x+0.349 3,r^2=0.999 5;Y=0.036x+0.223 71,r^2=0.999 2;Y=0.033x+0.284 4,r^2=0.999 1;Y=0.039 9x+0.255 1,r^2=0.999 1(x为葡萄糖醛酸浓度,y为吸收度)。在角膜、虹膜、玻璃体及房水中,葡萄糖醛酸在1.5-30μg/ml、0.5-20μg/ml、1.0-5.0μg/ml、0.5-1.5μg/ml的相应范围内具有良好的线性关系。角膜、虹膜、玻璃体及房水的峰浓度分别为(29.03±0.38)μg/L、(16.83±0.12)μg/L、(9.62±0.41)μg/L、(1.51±0.43)μg/L。峰时间分别为(9.81±0.51)min、(58.53±0.54)min、(60.37±0.19)min、(61.78±0.52)min。结论魟鱼软骨多糖滴眼后较快地作用于眼角膜组织,给药10 min左右在兔眼角膜中达至最大药物浓度,60 min后在房水中达到最大浓度。Objective To study ocular pharmacokinetic of Ray cartilage glycosaminoglycans eye drops(RCG) and determine the RCG concentration by UV-visible spectroscopy in rabbit eyes cornea, iris, vitreous and aqueous humor. Methods Twenty rabbits were randomly divided into 10 groups. The cornea, iris, vitreous and aqueous humor was collected at 10 min, 20 min, 30 min, 60 min, 90 min, 120 min, 180 min, 240 min, 300 min, 360 min for quantification analysis of drugs after application of RCG eye drops in the rabbit eyes. The concentration of RCG was detected using UV-visible spectrophotometry and the parameters were calculated. Results The linear regression equation of Glucuronide in cornea, iris, vitreous and aqueous humor were Y= 0.029 1 x + 0.349 3, r^2 = 0.999 5; Y = 0.036 x + 0.223 71, r^2 = 0.999 2; Y = 0.033 x + 0.284 4, r^2 = 0.999 1; Y = 0.039 9 x+ 0.255 1, r^2 =0.999 1(x: glucuronide concentrations, Y: light absorption value), respectively. The glucuronide had good linearity with the 1.5-30 μg/ml, 0.5-20 μg/ml, 1.0-5.0 μg/ml, 0.5- 1.5 μg/ml concentration range in cornea, iris, vitreous and aqueous humor, respectively. Peak concentration of the cornea, iris, vitreous and aqueous humor were 29.03±0.38 μg/L, 16.83±0.12 μg/L, 9.62±0.41 μg/L, 1.51±0.43 μg/L, respectively with the peak time of 9.81±0.51 min, 58.53±0.54 min, 60.37±0.19 min, 61.78±0.52 min, respectively. ConclusionRCG has the maximum drug concentration at about 10 min after administration in the rabbit cornea, and it reaches the maximum concentration at about 60 min after administration in the aqueous humor.
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