胆管上皮细胞与缺血再灌注损伤的研究进展  

Advances in biliary epithelial cell and ischemia-reperfusion injury

作　　者：谢芳[1] 罗渝昆[1] 唐杰[1] 

机构地区：[1]解放军总医院超声科,北京100853

出　　处：《解放军医学院学报》2015年第8期857-859,862,共4页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金面上项目(81271588)~~

摘　　要：随着肝移植术后胆道并发症研究的进展,缺血再灌注损伤越来越受到关注。然而,关于胆管上皮细胞与缺血再灌注损伤的相关研究尚少。目前,缺血再灌注损伤引起的胆道病变临床诊治相当棘手,其发病机制是多方面的,主要包括能量代谢紊乱、器官缺血产生的微血管功能障碍以及再灌注损伤引起的炎症免疫反应。本文对肝移植后胆管缺血再灌注损伤的病理生理学机制、影像学诊断及药理学防治的研究状况作一系统分析,以揭示缺血再灌注损伤与胆管疾病之间的关系,为肝移植术后胆道并发症的临床诊治提供有价值的信息。With the progress of research in biliary tract complications after liver transplantation, ischemia-reperfusion injury is attracting more and more attention. However, studies on biliary epithelial cell associated with ischemia-reperfusion injury are rarely few. Currently, the clinical diagnosis and treatment of biliary tract diseases caused by bile duct ischemia-reperfusion injury is a tricky one. The pathogenesis of bile duct ischemia-reperfusion injury is various, mainly including： energy metabolism disorders, microvascular dysfunction caused by organ ischemia, and inflammatory immune response triggered by reperfusion injury. Therefore, this review highlights the pathophysiology mechanism of bile duct ischemia-reperfusion injury, and discusses examples of imaging diagnosis and innovative therapeutic approaches based on these mechanistic findings, as well as gains new insight into the relationship between ischemia-reperfusion injury and bile duct diseases, in order to provide valuable information for the clinical diagnosis and treatment of biliary complications after liver transplantation.

关 键 词：胆管上皮细胞 缺血再灌注损伤 胆管周围血管丛 炎症免疫损伤 超声造影 

分 类 号：R657.3[医药卫生—外科学]