呕吐毒素对断奶仔猪外周血液中CD4^+、CD8^+淋巴细胞及抗氧化水平的影响  

Effects of deoxynivalenol on CD4^+ and CD8^+ lymphocytes and the antioxidant capacity of the peripheral blood of piglets

作　　者：姬长云 程汉奎 张静洁[1] 邓超[1] 钟佳莲[1] 李维铖[1] 邓衔柏[1] 

机构地区：[1]华南农业大学兽医学院,广东广州510642

出　　处：《中国兽医杂志》2015年第7期3-6,共4页Chinese Journal of Veterinary Medicine

基　　金：国家973计划资助项目(2009CB118805)

摘　　要：为了探讨低剂量呕吐毒素对断奶仔猪外周血液中CD4+和CD8+淋巴细胞及抗氧化水平的影响,将用10头平均体重为(7.70±1.00)Kg的三元杂交断奶仔猪,随机分成两组,对照组(基础饲粮)和脱氧雪腐镰刀菌烯醇(DON)组(基础饲粮+DON),试验开始前以及第8、16、24、36天采取仔猪前腔静脉静脉血液检测CD4+、CD8+淋巴细胞和CAT、GSH-Px、SOD、MDA的活性。结果对照组与DON组的CD4+、CD8+淋巴细胞差异都不显著,但是血清CAT、GSH-Px、SOD、MDA的活性都会发生明显变化。2 mg/Kg低剂量DON污染饲粮对断奶仔猪外周血液的CD4+、CD8+淋巴细胞不产生明显影响,对血清中抗氧化体系平衡会产生一定的损害。This experiment was conducted to investigate the effect of low dose of deoxynivalenol on CD4^＋and CD8^＋lymphocytes and the levels of the antioxidantion system of the peripheral blood of piglets.A total of 10 crossbred weaner piglets with an average body weight of（7.70±1.00）kg were randomly assigned to 2 groups. The 2 groups were as follows：control group（a basal diet）,DON group（the basal diet ＋ DON）. In order to detect CD4^＋,CD8^＋lymphocytes and the activity of CAT,GSH-Px,SOD and MDA,the precava blood were extracted from piglets at the 8,16,24,36 and the day before. [Result and conclusion] Compared with the control group,CD4^＋and CD8^＋lymphocytes showed no significant difference. low dose of DON（2 mg/kg）had no obvious influence on the levels of Swine fever antibody and CD4^＋and CD8^＋lymphocytes in peripheral blood of piglets.But it could disrupt the balance of the oxidation and antioxidantion system in the serum.

关 键 词：呕吐毒素 抗氧化 淋巴细胞 仔猪 

分 类 号：S858.28[农业科学—临床兽医学]