山茱萸主要有效成分的脑保护作用及其分子机制研究进展  

Progress on neuroprotective effects and underlying molecular mechanisms of Cornus officinalis' s primary component

作　　者：蔡小军[1] 邵南齐[2] 宋惠珠[1] 李在望[1] 温浩[1] 

机构地区：[1]南京医科大学附属无锡市人民医院,江苏无锡214023 [2]郑州澍青医学高等专科学校基础医学部,河南郑州450064

出　　处：《中国生化药物杂志》2015年第1期181-184,共4页Chinese Journal of Biochemical Pharmaceutics

基　　金：无锡市科技发展基金项目(SCZ00N1135)

摘　　要：缺血性脑血管病以其高发病率、高致残率和高病死率严重威胁着人们的健康和生活质量。缺血缺氧可破坏血脑屏障(blood brain barrier,BBB)结构和功能,并进一步触发脑组织损伤。山茱萸主要有效成分莫诺苷可通过保护神经元细胞、改善氧化应激状态、抑制炎症反应等多种途径缓解脑缺血。本文综述山茱萸及其主要有效成分脑缺血后发挥神经保护作用的分子机制,以探讨其治疗靶点及临床应用价值。Ischemic cerebrovascular disease with high incidence,mortality and disability,brings a serious threat to human health and quality of life. Ischemia and hypoxia can damage the structural components,function of blood-brain barrier（ BBB） and futher injury brain tissue. Morroniside,the primary component of Cornus officinalis,could alleviate cerebral ischemia though multiple approaches such as protecting neuronal cells,inhibiting oxidative stress and inflammation. This paper reviewed recent progresses in the research on cornus officinalis＇ primary component＇s neuroprotection and its underlying molecular mechanisms in order to clarify its therapeutic targets and value of clinical application.

关 键 词：山茱萸 脑缺血 分子机制 氧化应激 炎症反应 细胞凋亡 

分 类 号：R285[医药卫生—中药学]