茵碧方治疗慢性乙型肝炎肝硬化高胆红素血症临床疗效观察  

Clinical Effect of “Yinbi Formula”in Treatment of Chronic Hepatitis B with Cirrhosis and Hyperbilirubinemia

作　　者：朱晓骏[1,2] 孙学华[1,2] 周振华 黄凌鹰[1,2] 何峥[1] 张鑫 杨婉凤[1] 高月求[1,2] 

机构地区：[1]上海中医药大学附属曙光医院肝病科,上海201203 [2]上海市中医临床重点实验室,上海201203

出　　处：《上海中医药大学学报》2015年第4期16-19,共4页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金资助项目(81403351);上海市卫生局中医药科研基金资助项目(2010QL007A);上海市"杏林新星"计划项目(ZYSNXD-RCXLXX-20130021);国家科技重大专项项目(2012ZX10005004-002;2012ZX10005010-002-003);教育部高等学校博士学科点专项科研基金资助项目(20123107110003);上海市科委科研计划资助项目(11411951600;13401902900;14ZR1441900;14YF1411600);上海市中医药事业发展三年行动计划(重大研究)项目(ZYSNXD-CC-ZDYJ015;ZYSNXD-CC-ZDYJ048);上海中医药大学预算内项目(2012JW45;2013JW40);中国肝炎防治基金会王宝恩肝纤维化研究基金资助项目(CFHPC20131045;CFHPC20131046);上海市重中之重临床医学中心(中医肝病)建设项目

摘　　要：目的:观察茵碧方治疗慢性乙型肝炎肝硬化高胆红素血症的临床疗效。方法:将96例脾虚兼湿热瘀血型慢性乙型肝炎肝硬化高胆红素血症患者随机分为治疗组(48例)和对照组(48例)。所有患者均进行西医常规的抗病毒治疗,治疗组患者加服茵碧方治疗,对照组患者加服熊去氧胆酸胶囊治疗,治疗周期为12周。评价两组患者的临床疗效及中医证候疗效,比较两组患者的总胆红素(TBIL)、直接胆红素(DBIL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)水平的变化。结果:1临床疗效:治疗组的总有效率为69.8%,对照组为17.8%,治疗组的疗效优于对照组(P<0.01)。2中医证候疗效:治疗组的中医证候疗效总有效率为62.8%,对照组为28.9%,治疗组的疗效优于对照组(P<0.01)。3肝功能指标:治疗后,治疗组患者的TBIL、DBIL水平较治疗前均明显下降(P<0.01),且治疗组患者的TBIL、DBIL水平明显低于对照组(P<0.05);治疗前后两组患者的ALT、AST、GGT、ALP水平的组内及组间比较,差异均无统计学意义(P>0.05)。结论:茵碧方治疗慢性乙型肝炎肝硬化高胆红素血症患者(脾虚兼湿热瘀血型),能够有效降低患者的胆红素水平,改善患者的临床症状。Objective ： To observe the effect of ＂Yinbi Formula＂ in the treatment of chronic hepatitis B with cirrhosis and hyperbilirubinemia. Methods： Ninety-six patients with chronic hepatitis B, cirrhosis and hyperbilirubinemia of spleen- deficiency with damp-heat and blood-stagnation type were randomly divided into treatment group （48 eases） and eontrol group （48 eases）. All the patients were treated with antiviral therapy, and the patients in the treatment group were treated with ＂Yinbi Formula＂ and the patients in the control group were treated with ursodesoxycholie acid capsule additionally, with a course of 12 weeks. The clinical effect and the Chinese medical syndrome effect were evaluated, and the levels of TBIL, DBIL, ALl＇, AST, GGT and ALP were detected. Results：①Clinical effect： The total effective rates of treatment group and control group were 69.8% and 17.8% respectively, and the effect of treatment group was better than that of the control group （ P 〈 0.01 ）. ②Chinese medical syndrome effect ： The total effective rates of treatment group and control group were 62.8% and 28.9% respectively, and the effect of treatment group was better than that of the control group （P 〈0.01 ）. ③Liver function indexes： After treatment, the levels of TBIL and DBIL in the treatment group were decreased （P 〈0. 01 ）, and the levels of TBIL and DBIL in the treatment group were lower than those in the control group （ P 〈 0.05 ）. There were no statistical differences on the levels of ALT, AST, GGT and ALP between the two groups before and after treatment （P〉 0.05 ）. Conclusion：＂ Yinbi Fomula＂ can decrease the level of bilirubin and improve the symptoms for patients with chronic hepatitis B, eirrhosis and hyperbilirubinemia of spleen-deficieney with damp-heat and blood-stagnation type.

关 键 词：慢性乙型肝炎 肝硬化 高胆红素血症 茵碧方 

分 类 号：R259[医药卫生—中西医结合]