急性心肌梗死患者γ-GGT水平与冠状动脉无复流的相关性分析  被引量:3

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作  者:郭艳霞[1] 陆士奇[1] 何磊磊[1] 李静[1] 肖接承[1] 

机构地区:[1]苏州大学附属第一医院,215006

出  处:《浙江临床医学》2015年第9期1494-1496,共3页Zhejiang Clinical Medical Journal

摘  要:目的探讨急性心肌梗死患者血清谷氨酰转移酶(γ-GGT)水平与经皮冠状动脉介入治疗(PCI)术后冠状动脉无复流的相关性。方法急性心肌梗死并行急诊PCI的患者282例,根据冠状动脉造影心肌梗死溶栓治疗(TIMI)评分分为再灌注组(264例)和无复流组(18例)。比较包括γ-GGT在内的血常规和生化的部分指标并进行统计学分析。结果无复流组中左室射血分数、白细胞总数、中性粒细胞值、中性粒细胞/淋巴细胞比值、血糖、γ-GGT、应用主动脉球囊反搏术与再灌注组比较,差异有统计学意义(P〈0.05)。且无复流组患者住院期间的主心脏不良事件的发生率(22.2%)与再灌注组比较,差异有统计学意义(P〈0.05)。结论γ-GGT可能为急性心肌梗死患者PCI术后冠状动脉无复流发生的危险因素。Objectives To discuss the correlation of γ-GGT levels and coronary no-reflow after percutaneous coronary intervention in patients with acute myocardial infarction. Methods Select 282 patients with acute myocardial infarction undergone primary percutaneous coronary intervention from September 2013 to March 2014 .According to thrombolysis in myocardial infarction ratings in coronary angiography, these patients were divided into reperfusion group ( 264 cases ) and no-reflow group ( 18 cases ) . Compare γ -GGT and some other biochemical indicators and carry out statistical analysis. Results Comparing to the reperfusion group, patients in no-reflow group had a worse level of left ventricular ejection fraction ( EF values, 0.456 ± 0.073 ) , WBC ( 10.946 ± 5.513 ) , neutrophil values ( 9.047± 5.587 ) , neutrophil / lymphocyte ratio ( 10.169 ± 12.366 ) , glucose ( 9.074± 4.091 ) , γ-GGT ( 48.50± 30.924 ) , preoperative use of intra-aortic balloon counter-pulsation ( IABP ) ( 3 ( 16.7% ) ) . The difference was statistically significant ( P〈0.05 ) . Furthermore, occurrence rates of major adverse cardiac events ( MACE ) in no-reflow group (22.2%) were higher than reperfusion group ( 6.1% ) . The difference was also statistically significant ( P=0.032, 〈0.05 ) . Conclusion γ-GGT maybe a new indicator of coronary no-reflow after percutaneous coronary intervention in patients with acute myocardial infarction.

关 键 词:急性心肌梗死 经皮冠状动脉介入治疗 冠状动脉无复流 谷氨酰转移酶 

分 类 号:R543.3[医药卫生—心血管疾病]

 

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