水杨酸类药物的新用途——改善2型糖尿病患者糖代谢状态  

New application of salicylates in improving glucose metabolism in patients with type 2 diabetes mellitus

作　　者：江昕[1] 刘芳[1] 邓华聪[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,重庆400016

出　　处：《重庆医科大学学报》2015年第7期1029-1032,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金面上资助项目(编号:81270911);国家临床重点专科建设资助项目(编号:财社[2011]170号)

摘　　要：慢性低度炎症参与胰岛素抵抗及2型糖尿病的发生发展。临床资料显示经典的水杨酸类抗炎药能有效改善2型糖尿病患者糖代谢状态,但其具体作用机制尚不明确。研究表明,除了抑制炎症反应外,水杨酸类药物还能通过减轻氧化应激、激活腺苷酸活化蛋白激酶、降低游离脂肪酸水平等多种途径发挥降糖效应。本文就近年来水杨酸类药物对糖代谢作用的研究成果进行综述,从而为该类药物在2型糖尿病应用中的深入研究提供新的思路。Chronic low-grade inflammation participates in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Clinical data show that salicylates can improve glucose metabolism in patients with type 2 diabetes. However,its hypoglycemic mechanism is unclear. Some studies have indicated that in addition to inhibiting inflammation,salicylates can reduce glycemia through other ways such as alleviating oxidative stress,activating AMP-activated protein kinase and decreasing free fatty acid level. This article reviewed the literature in recent years about the effect of salicylates on glucose metabolism,which will provide new ideas for the further studies of the application of salicylates in type 2 diabetes mellitus.

关 键 词：水杨酸 2型糖尿病 炎症 

分 类 号：R587.1[医药卫生—内分泌]