胃疾病患者血清胃蛋白酶原的水平变化及其临床意义  

The changes of serum pepsinogen levels and its clinical significance in patients with gastric diseases

作　　者：李凤[1] 蒲泽晏 梁艳丽[1] 尹凤辉 黄雪梅[1] 魏容[1] 冯簏洁 魏佳希 

机构地区：[1]四川省遂宁市中心医院,四川遂宁629000

出　　处：《实用医院临床杂志》2015年第5期125-126,共2页Practical Journal of Clinical Medicine

摘　　要：目的了解胃蛋白酶原(PG)在胃疾病患者血中的变化情况,探讨其临床应用价值。方法根据胃镜检查及病理报告结果选取我院住院胃疾病患者319例,其中胃癌51例,胃十二指肠溃疡92例,胃炎160例,胃十二指肠息肉16例。另选同期健康体检者无上消化道症状和无胸腹部手术者100例为对照组。采用时间分辨荧光免疫分析检测法检测胃蛋酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)含量,计算其比值(PGⅠ/PGⅡ)。结果胃癌、胃十二指肠溃疡、胃炎及胃十二指肠息肉患者PGⅠ、PGⅡ均明显高于对照组(P<0.05),PGⅠ/PGⅡ比值明显低于对照组(P<0.01)。结论 PGI、PGⅡ及PGⅠ/PGⅡ检测结果可作为胃部疾病的一种检测手段。Objective To investigate the changes of serum pepsinogen（PG） in patients with gastric diseases and its value in clinical application. Methods According to the resuhs of gastroscopy and pathology reports,we selected 51 cases with gastric cancer, 92 cases with gastric and duodenal ulcer, 160 cases with gastritis, and 16 cases with gastric and duodenal polyps from inpatients between January 1,2014 and December 31,2014 as the observation subjects. One hundred healthy persons without upper gastrointestinal symptoms and no thoracic and abdominal operation from department of physical examination were selected as control group. The levels of serum PG I and PG II were detected with a Time Resolved Fluoro Immunoassay. The ratio （ PG I / PG II） was calculated. Results Through statistical analysis, the levels of serum PG I and PG II in cases of gastric cancer, gastric and duodenal ulcer, gastritis group, and gastric and duodenal polyps were significantly higher than that in the control group（P 〈 0. 01 ）. PG I/PG II ratio was significantly lower than that in the controls （P 〈 0. 01 ）. Conclusion PGI, PG II and PG I/PG II ratio can be used as a diagnostic and differential diagnostic index of stomach diseases.

关 键 词：胃蛋白酶原 时间分辨荧光免疫法 胃癌 胃溃疡 胃炎 胃息肉 

分 类 号：R446.62[医药卫生—诊断学]