胰高血糖素样肽-2与肠道黏膜免疫  

Glucagon-like peptide-2 and intestinal mucosal immunity

作　　者：雷秋成[1,2] 王新颖[1,2] 

机构地区：[1]中国人民解放军南京军区南京总医院普通外科 [2]南方医科大学南京临床医学院全军普通外科研究所,江苏省南京市210002

出　　处：《世界华人消化杂志》2015年第23期3736-3741,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81470797~~

摘　　要：胰高血糖素样肽-2(glucagon-like peptide-2,GLP-2)是由肠道L细胞合成分泌的、由33个氨基酸残基组成、分子量为3.9 k Da的单链多肽类激素.他是一种肠上皮特异性生长因子,具有促进肠道营养物质的吸收,增强肠道屏障功能,并且可促进损伤肠黏膜的生长与修复及抑制细胞凋亡,对维持肠黏膜的连续性与完整性具有重要的意义.这些特点使GLP-2迅速成为了当今肠屏障功能领域的研究热点.目前的研究多关注GLP-2在营养吸收与保护肠道机械屏障方面的作用,对于其在肠道黏膜免疫中的保护作用报道相对较少.本文就GLP-2在肠道黏膜免疫系统中的作用及其可能机制作一阐述.Glucagon-like peptide-2（GLP-2） is a single chain polypeptide hormone with a molecular weight of 3.9 kDa, which is secreted by L cells of the intestine. GLP-2 is a specific intestinal epithelial growth factor, and it can promote the repair of intestinal mucosa injury, inhibit apoptosis, improve the intestinal absorption of nutrients, and strengthen the intestinal barrier function. GLP-2 also plays an important role in maintaining the continuity and integrity of the intestinal mucosa. These characteristics make GLP-2 become the current research hotspot in the field of gastrointestinal barrier function. The main focus of previous studies is on nutrient absorption and protection of the intestinal mechanical barrier, and there have been relatively scarce studies on the protective effect of GLP-2 on intestinal mucosal immune barrier. This article reviews the role of GLP-2 in intestinal mucosal immunity and the possible mechanisms.

关 键 词：胰高血糖素样肽-2 肠道黏膜免疫 分泌型IGA 

分 类 号：R392[医药卫生—免疫学]