七氟醚的神经保护作用及其机制  

The research progress on the neuroprotective effect and mechanism of sevoflurane

作　　者：邓斌[1,2] 邓克强 吴水祥 党杨杰 徐礼鲜[1] 

机构地区：[1]军事口腔医学国家重点实验室,第四军医大学口腔医学院麻醉科,西安710032 [2]厦门警备区医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2015年第9期843-846,857,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金面上项目（81471265）;第四军医大学博士学位论文资助项目（2013-D03）

摘　　要：背景近年来吸入性麻醉药预处理和后处理概念的提出，为中枢神经系统（central nervous system，CNS）损伤等相关疾病的治疗提供了新思路。有证据表明，低浓度的吸入麻醉药七氟醚预处理和后处理对脑缺血等CNS损伤具有一定的神经保护作用。目的对七氟醚的神经保护作用及其机制研究进行综述，为今后七氟醚的基础与临床研究提供参考。内容阐述吸入性麻醉药预处理和后处理的概念，分析七氟醚预处理及后处理的神经保护作用及其机制。趋向深入研究七氟醚神经保护作用及机制，可为其临床应用提供更充分的理论依据。Background In recent years, the concept of volatixe anestheties preconditioning and postconditioning provide an important solution for the central nervous system （CNS） damage and treatment. Several studies showed that low concentrations of sevoflurane preconditioning or postconditioning had neuroprotective effect. Objective In this paper, the neuroprotective effect and mechanism of sevoflurane were discussed in this paper which providing for basic and clinical research of sevoflurane in future. Content We reviewed the the concept of volatixe anestheties preconditioning and postconditioning, the neuroprotective effect and mechanism of sevoflurane preconditioning and postconditioning. Trend With the deep understanding of neuroprotective effect and mechanism of sevoflurane, it will provide more comprehensive theoretical basis and clinical application for the future research.

关 键 词：吸入麻醉药 七氟醚 预处理 后处理 神经保护 

分 类 号：R614[医药卫生—麻醉学]