氮氧自由基长链衍生物的设计合成与结构表征  

Synthesis and Characterization of Nitronyl Nitroxide Derivatives with Long Chain

作　　者：景临林[1] 马慧萍[1] 樊鹏程[1] 贾正平[1] 

机构地区：[1]兰州军区兰州总医院药剂科,甘肃兰州730050

出　　处：《精细化工中间体》2015年第4期20-22,25,共4页Fine Chemical Intermediates

基　　金：国家自然科学基金项目(81202458);全军医药科研"十二五"面上项目(CLZ12JA04);中国博士后科学基金(2012M521926);甘肃省自然科学基金(1308RJYA06)

摘　　要：以对羟基苯甲醛、4种长链溴代烷为原料。通过醚化、缩合和氧化3步反应得到4个氮氧自由基长链衍生物。反应路线简单，条件温和，收率较高，总收率为38％～55％（以4-羟基苯甲醛计）。产物结构经IR、EPR、ESI—MS和元素分析确证。Four nitronyl nitroxide derivatives with long chain were synthesized via etherification, condensation and oxidation reactions using 4-hydroxybenzaldehyde and four bromoalkanes with long chain as starting material. The synthetic route is simple with mild reaction conditions and high yield. The total yield was38%-55% （calculated from the 4-hydroxybenzaldehyde）. The structures were characterized by IR, ESI-MS, ERP and elemental analysis.

关 键 词：氮氧自由基 对羟基苯甲醛 溴代烷 

分 类 号：TQ463.5[化学工程—制药化工]