可降解型抗癌靶向药物控释载体材料聚丙交酯乙交酯的合成研究  

Synthesis and Characterization of Poly(L-lactide-co-glycolide)as the Material for Degradable Anti-cancer Drug Targeting Carrier

作　　者：贺灵芝[1] 旷文安[2] 陈爱军[1] 

机构地区：[1]湖南环境生物职业技术学院医药学院,湖南衡阳421005 [2]南华大学附属第一医院,湖南衡阳421001

出　　处：《精细化工中间体》2015年第4期26-27,60,共3页Fine Chemical Intermediates

基　　金：湖南环境生物职业技术学院2014年度院长青年课题资助项目

摘　　要：以L-丙交酯与乙交酯(25%/75%,m/m)为原料,异辛酸亚锡为引发剂进行开环聚合,得到了可用于抗癌靶向药物控释载体的单羟基的功能性低分子材料聚丙交酯乙交酯(75/25)。用红外光谱、氢核磁共振光谱进行了表征,凝胶渗透液相色谱测定其相对分子量为3 800 Da,分子量分布指数为1.3。Polylactide-co-glycolide （75/25）was synthesized by ring-opening glycolide as the starting materials and stannous octoate as the initiator; The characterized by infrared spectrum and proton nuclear magnetic resonance results also showed that PLGA with a relative molecular mass of 3 800 Da and copolymerization using lactide and obtained polymeric materials were spectrum. The GPC experimental dispersity of 1.3 was obtained.

关 键 词：聚丙交酯乙交酯 生物材料 可降解 

分 类 号：R318.08[医药卫生—生物医学工程]