7-苯乙酰胺基-3-氯甲基头孢烷酸对甲氧基苄酯C-3位卤离子交换反应研究  

Study on the Reaction of Halogen Ion Exchange GCLE C-3 bit

作　　者：王宗利 侯仲轲 吕秋波 张宜仲 田黎黎 刘冲 

机构地区：[1]浙江国邦药业有限公司,浙江上虞312369

出　　处：《精细化工中间体》2015年第4期42-45,共4页Fine Chemical Intermediates

摘　　要：通过调整7-苯乙酰胺基-3-氯甲基头孢烷酸对甲氧基苄酯(GCLE)的C-3位卤素交换试剂的种类及用量,改变卤素交换反应水量,控制反应温度,明确反应时间,优化了GCLE的C-3位卤素交换的反应条件。结果表明:在n(碘化钠)∶n(溴化钠)∶n(GCLE)=0.1∶0.9∶1.0,v(水)∶w(GCLE)=1∶1,反应温度35℃,反应时间5 h的条件下,GCLE转化率99.71%,选择性97.63%。The reaction conditions for GCLE[（6R-trans）-5-Thia-l-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-chloromethyl-8-oxo-7-[（phenylacetyl）amino]-diphenylmethyl ester] C-3 bit halogen exchange reaction were evaluated including different kind of type and amount of reagents, loading of water, and different reaction temperatures and time. The results indicated that the average conversion rate of GCLE was 99.71%, the average selectivity of the reaction was 97.63%, under the following reaction conditions： the molar ratio of sodium iodide, sodium bromide, GCLE is 0.1：0.9：1.0; the ratio of water volume and quality of GCLE is 1：1; reaction temperature was 35~C and reaction time was 5 h.

关 键 词：GCLE 卤素交换 反应选择性 

分 类 号：TQ254[化学工程—有机化工]