我院碳青霉烯类药物使用量与肺炎克雷伯菌耐药相关性分析  

Relationship between Carbapenems Dosage and the Resistance of Klebsiella pneumonia

作　　者：吴芳[1] 刘祖德[1] 程志英[1] 

机构地区：[1]武警总医院药剂科,北京100039

出　　处：《中国药房》2015年第26期3660-3662,共3页China Pharmacy

摘　　要：目的：为临床合理使用抗菌药物提供参考。方法：按季度统计2013年10月1日-2014年9月30日我院碳青霉烯类药物的使用量、培养出的肺炎克雷伯菌的菌株数（共计271株）在5个主要使用科室分布情况及其对碳青霉烯类药物的耐药率,分析碳青霉烯类药物的使用量与肺炎克雷伯菌耐药的相关性。结果：碳青酶烯类药物的使用科室较为集中,主要为神经外科、重症监护室（ICU）、移植科和呼吸科,与耐碳青酶烯类肺炎克雷伯菌检出的科室基本一致。而且,随着碳青霉烯类药物的使用量增加了64.24%~360.63%不等,肺炎克雷伯菌的耐药率亦增加近10%。结论：肺炎克雷伯菌耐药率与碳青霉烯类药物使用量呈正相关,控制碳青霉烯类药物使用量,可以延缓肺炎克雷伯耐药菌的产生。OBJECTIVE：To provide reference for rational use of antibiotics in the clinic. METHODS：The study quarterly count the dosage of carbapenems,the department distribution of cultured K. pneumonia（271 strains） during Oct. 1st 2013-Sept.30 th 2014,and it＇s resistant rates to carbapenems and then investigate the correlation of dosage of carbapenem and drug-resistance of K. pneumoniae. RESULTS：Carbapenem drugs are mainly used in these departments,such as neurosurgery department,ICU and the departments of transplantation and respiratory. Carbapenem-resistant K. pneumonia was also detected in these departments. Moreover,with the usage of carbapenem increased by from 64.24% to 360.63%,and the resistant rates of K. pneumonia increased by nearly 10%. CONCLUSIONS：The resistance rates of K. pneumonia is positively related to the amount of carbapenem;the amount control of carbapenems can delay the generation of K. pneumonia.

关 键 词：碳青霉烯类药物 肺炎克雷伯菌 耐药性 细菌培养 药敏试验 

分 类 号：R969.1[医药卫生—药理学] R978.1[医药卫生—药学]