马来酸桂哌齐特及有关物质的HPLC法测定  

Determination of Cinepazide Maleate and Its Related Substances by HPLC

作　　者：周一萌[1] 周斌[1] 

机构地区：[1]中国医药工业研究总院上海医药工业研究院,上海201203

出　　处：《中国医药工业杂志》2015年第9期1010-1012,共3页Chinese Journal of Pharmaceuticals

摘　　要：建立了高效液相色谱法测定马来酸桂哌齐特及有关物质的含量。使用Phenomenex Hyper Clone BDS C18色谱柱,流动相为0.3%三乙胺溶液（用磷酸调至p H 7.5）∶甲醇（49∶51）,检测波长230 nm。马来酸桂哌齐特与有关物质的分离度良好。马来酸桂哌齐特线性范围为0.01~1 mg/ml,平均回收率为99.83%,RSD为0.37%。An HPLC method was established for the determination of cinepazide maleate and its related substances. A Phenomenex HyperClone BDS C18 column was used with the mobile phase of 0.3 % triethylamine （adjusted to pH 7.5 with phosphoric acid） ： methanol （49 ： 51） at the detection wavelength of 230 nm. Cinepazide maleate and its related substances were well separated. The calibration curve for cinepazide maleate was linear in the concentration range of 0.01 - 1 mg/ml. The average recovery was 99.83 % , with RSD of 0.37%

关 键 词：马来酸桂哌齐特 有关物质 高效液相色谱 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.72[化学工程—制药化工]