载脂蛋白A5基因多态性与代谢综合征的相关性  

Association between apolipoprotein A5 genepolymorphism and metabolic syndrome

作　　者：冯佳[1,2] 施秉银[1] 刘淑[1] 高爱博[1] 

机构地区：[1]西安交通大学医学部第一附属医院内分泌科,陕西西安710061 [2]西安交通大学医学部附属市九院内分泌科,陕西西安710054

出　　处：《西安交通大学学报（医学版）》2015年第5期661-666,共6页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的探讨载脂蛋白A5（apoA5）基因-1131T〉C（rs662799）及1259T〉C（rs2266788）单核苷酸多态性与代谢综合征的关系。方法采用聚合酶联反应及限制性片段长度多态性分析方法测定110例代谢综合征（MS）患者及110例健康对照组的apoA5基因-1131T〉C（rs662799）及1259T〉C（rs2266788）二位点的基因型,并检测血糖、血脂等指标,比较不同基因型与MS患病风险的关系。结果 -1131CC基因型携带者体重指数（BMI）、甘油三酯（TG）较TC、CC基因型升高,存在统计学差异（P〈0.05）。1259CC基因型携带者TG、糖化血红蛋白（HBA1C）较TC、CC基因型升高,存在统计学差异（P〈0.05）。-1131CC基因型携带者发生MS的风险是TT基因型携带者的4.5倍（OR=4.504,95%CI：1.766~11.490,P=0.002）,且都得到统计学支持。结论 apoA5-1131T〉C（rs662799）基因多态性与MS的发病可能相关;而apoA5 1259T〉C（rs2266788）基因多态性与MS的发病无明显相关性。Objective To investigate the relationship between apolipoprotein A5（apoA5）gene and metabolic syndrome（MS）.Methods Polymerase chain reaction and technique of restriction fragment length polymorphism were used to determine the genotypes of apoA5-1131TC（rs662799）and 1259TC（rs2266788）in 110 patients with MS and 110 healthy control subjects.Results The levels of BMI and TG of subjects with apoA5-1131 CC genotype were higher than those of subjects with TC and CC genotype（P〈0.05）.The levels of TG and HBA1 C of subjects with apoA5 1259 CC genotype were higher than those of subjects with TC and CC genotype（P〈0.05）.The risk of MS in subjects with apoA5-1131 CC genotype was 4.5 times higher than that in subjects with TT genotype（OR=4.504,95% CI：1.766-11.490,P=0.002）.Conclusion The genetic polymorphism of apoA5-1131TC（rs662799）may contribute to an increased risk of MS while that of apoA5 1259TC（rs2266788）has no obvious relationship with the occurrence of MS.

关 键 词：载脂蛋白A5 代谢综合征 基因多态性 血脂 遗传 

分 类 号：R589.9[医药卫生—内分泌]