维吾尔族和汉族寻常型天疱疮患者61例分析  

Clinical analysis of 61 patients with pemphigus vulgaris of Han or Uygur nationality

作　　者：刘勇[1] 赵香华 孙景英[1] 普雄明[1] 吴卫东[1] 

机构地区：[1]新疆维吾尔自治区人民医院皮肤病与性病科,乌鲁木齐830001 [2]新源县人民医院皮肤科

出　　处：《国际皮肤性病学杂志》2015年第5期277-279,共3页International Journal of Dermatology and Venereology

摘　　要：目的 探讨新疆维吾尔族和汉族寻常型天疱疮的临床特点和治疗方案.方法 回顾性分析61例维吾尔族和汉族寻常型天疱疮住院患者的资料.结果 61例患者中,44例（72.13％）合并口腔和（或）外阴黏膜溃疡,49例（80.33％）尼氏征阳性,52例（85.25％）伴不同程度瘙痒,30例（49.18％）合并低蛋白血症.轻中型患者单用糖皮质激素疗效较好,重型患者联合免疫抑制剂或丙种球蛋白疗效较好.维吾尔族患者和汉族患者相比较,其黏膜受累、血细胞沉降率增快和低蛋白血症显著增加,差异有统计学意义（P＜0.05）.结论 61例寻常型天疱疮患者中,维吾尔族重型患者所占比例高于汉族.Objective To assess clinical features of and treatment protocols for pemphigus vulgaris （PV） in patients of Han or Uygur nationality in Xinjiang Uygur Autonomous Region.Methods Clinical data were collected from 61 inpatients with PV of Han or Uygur nationality,and analyzed retrospectively.Results Of the 61 patients,44 （72.13%） had oral and/or vulval ulcer,49 （80.33%） positive Nikolsky＇s sign;52 （85.25%） suffered from different degrees of itching,and 30 （49.18%） from hypoproteinemia.Glucocorticoids alone are effective for mild to moderate PV,while immunosuppressive agents and gamma globulin should be combined to control severe PV.Compared with patients of Han nationality,those of Uygur nationality showed increased frequency of mucosal involvement,incidence of hypoproteinemia,and elevated blood sedimentation rate （all P 〈 0.05）.Conclusion In this study,the patients of Uygur nationality showed a higher proportion of severe PV cases compared with those of Han nationality.

关 键 词：天疱疮 临床方案 糖皮质激素类 维吾尔族 回顾性研究 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]