化斑颗粒的质量标准研究  

Quality Standards Research of Huaban Granules

作　　者：陆崟[1] 王银娟[1] 乔立业[1] 任海祥[1] 苏华[1] 

机构地区：[1]南京军区南京总医院制剂科,江苏南京210002

出　　处：《中华中医药学刊》2015年第9期2109-2111,I0006,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：全军医疗机构制剂标准提高科研专项课题重点项目(14ZJZ08)

摘　　要：目的：建立化斑颗粒的质量标准。方法：对处方中夏枯草、茯苓、赤芍、白芍和菊花进行薄层色谱鉴别;对夏枯草中的迷迭香酸进行高效液相色谱法含量测定。结果：薄层色谱鉴别斑点清晰,专属性强;迷迭香酸的浓度在1.656 48～26.503 68μg/m L之间,与峰面积呈良好的线性关系,R2=0.9999,平均回收率为102.18%,RSD为0.75%。结论：本制剂所定质量标准方法简便、合理、准确,可用于化斑颗粒的质量控制。Objective： To establish the quality standards of Huaban Granules. Methods： Xiakucao（Prunellae spica）,Fuling（Poria）,Chishao（Paeoniae radix rubra）,Baishao（Paeoniae radix alba） and Juhua（Chrysanthemi flos） were identified by thin layer chromatography（TLC）. The contents of rosmarinic acid in Xiakucao（Prunellae spica） were determined by high performance liquid chromatography（HPLC）. Results： TLC spots were clear with strong specificity. The linear relationship of rosmarinic acid content was good in the range of 1. 656 48 μg/m L to 26. 503 68 μg/m L（R2= 0. 9999） and the average recovery rate was 102. 18%（RSD = 0. 75%）. Conclusions： The method is simple,reasonable and accurate and can control the quality of Huaban Granules.

关 键 词：化斑颗粒 质量标准 薄层色谱法 高效液相色谱法 

分 类 号：R284.1[医药卫生—中药学]