麝香保心丸治疗冠心病心绞痛及对患者血清炎症因子的影响  

Shexiang Baoxin Pills in Treatment of Coronary Heart Disease Angina and Effect on Serum Inflammatory Factors of Patients

作　　者：谭昕[1] 太加斌[1] 方袁媛[1] 曹众毅[1] 楼静[1] 

机构地区：[1]杭州市萧山区第一人民医院药剂科,浙江杭州311200

出　　处：《中华中医药学刊》2015年第9期2184-2187,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省卫生厅科技计划项目(2008B160)

摘　　要：目的:探讨麝香保心丸治疗冠心病心绞痛及对患者血清炎症因子的影响。方法:选择2011年10月—2014年10月130例冠心病心绞痛患者作为研究对象,随机分成两组,各65例。对照组:接受硝酸异山梨酯、辛伐他汀、阿司匹林等常规药物治疗。观察组:接受硝酸异山梨酯、辛伐他汀、阿司匹林等常规药物治疗,同时口服麝香保心丸。结果:观察组总有效率81.5%高于对照组总有效率55.4%,差异具有统计学意义(P<0.01)。治疗后,观察组心绞痛发作频率(6.8±1.7)次/周、持续时间(3.3±1.2)min/次、心绞痛积分(8.1±3.2)分都低于对照组心绞痛发作频率(13.6±2.3)次/周、持续时间(5.5±1.8)min/次、心绞痛积分(12.5±4.3)分,差异均有统计学意义(P<0.01)。治疗后,观察组患者TG(1.76±0.46)mmol/L、TC(5.36±0.51)mmol/L、LDL-C(4.35±0.77)mmol/L都低于对照组患者TG(2.74±0.52)mmol/L、TC(6.68±0.74)mmol/L、LDL-C(5.31±0.98)mmol/L,差异均有统计学意义(P<0.01)。治疗后,观察组口服硝酸甘油后缓解时间(2.9±1.2)min及硝酸甘油用量(1.5±0.4)mg都少于对照组口服硝酸甘油后缓解时间(4.3±1.8)min及硝酸甘油用量(4.2±1.6)mg,差异均有统计学意义(P<0.01)。治疗后,观察组患者临床证候评分都低于对照组,差异均有统计学意义(P<0.01)。治疗后,观察组患者血清IL-6(7.9±2.0)pg/m L、HCY(24.1±5.3)pg/m L、hs-CRP(7.7±2.2)mol/m L、s CD40L(153.2±17.3)mol/m L都低于对照组患者血清血清IL-6(12.3±3.5)pg/m L、HCY(32.4±7.7)pg/m L、hs-CRP(11.3±3.8)mol/m L、s CD40L(179.4±20.1)mol/m L,差异均有统计学意义(P<0.01)。治疗后,观察组患者血清VCAM-1(421.1±97.3)pg/m L、MPO(90.7±8.5)pg/m L、MMP-9(113.7±13.2)pg/m L都低于对照组患者血清VCAM-1(497.2±102.5)pg/m L、MPO(112.7±15.3)pg/m L、MMP-9(149.6±18.8)pg/m L,差异均有统计学意义(P<0.01)。结论:麝香保心丸治疗冠心病心绞痛疗效确切,能够减轻患者局部炎症反应,调节血脂水平,并具有稳�Objective： To explore the curative effect of Shexiang Baoxin Pills in the treatment of coronary heart disease angina and effect on serum inflammatory factors of patients. Method： 130 cases of patients with angina pectoris of coronary heart disease were as the objects in October 2011—October 2014 in our hospital and were randomly divided into two groups,65 cases in each. Control group： isosorbide dinitrate and simvastatin and aspirin and other conventional drug treatment. Observation group： isosorbide dinitrate,aspirin,simvastatin,routine drug therapy,and oral Shexiang Baoxin pills.Results： Total effective rate of observation group was 81. 5%,higher than that of the control group＇s 55. 4%,with significant difference（P〈0. 01）. After treatment,the seizure frequency of angina pectoris（6. 8 ± 1. 7） times per week,duration（3. 3 ± 1. 2） min/integral time,angina socre 8. 1 ± 3. 2 of the observation group were lower than the control group＇s frequency of angina pectoris attack（13. 6 ± 2. 3） times per week,duration（5. 5 ± 1. 8） min/integral time,angina score（12. 5 ± 4. 3）,with a statistically significant difference（P〈0. 01）. After treatment,TG（1. 76 ± 0. 46） mmol/L,TC（5. 36 ± 0. 51） mmol/L,LDL-C（4. 35 ± 0. 77） mmol/L of the observation group were lower than the control group＇s TG（2. 74 ± 0. 52） mmol/L,TC（6. 68 ± 0. 74） mmol/L,LDL-C（5. 3 ± 0. 98） mmol/L and the difference was statistically significant（all P〈0. 01）. After treatment,the remission time after oral nitroglycerin（2. 9 ± 1. 2） min and dosage of nitroglycerin（1. 5 ± 0. 4） mg of the observation group were less than the control group＇s remission time oral nitroglycerin（4. 3 ± 1. 8） min and dosage of nitroglycerin（4. 2 ± 1. 6） mg and there were significant differences（P〈0. 01）.After treatment,the clinical symptom score of the observation group was lower than the control group＇s and there were statistically significant differences（P〈0. 01）. Aft

关 键 词：冠心病心绞痛 麝香保心丸 炎症因子 斑块 

分 类 号：R541.4[医药卫生—心血管疾病]