肿瘤血管化拟态分子形成机制的研究进展  

Molecular mechanism of tumor vasculogenic mimicry:research advances

作　　者：张吉刚[1] 张丹丹[1] 左艳华[2] 李晓宇[1] 李琴[1] 刘皋林[1] 

机构地区：[1]上海交通大学医学院第一人民医院临床药学科,上海200080 [2]青岛大学附属医院药剂科,青岛266003

出　　处：《国际药学研究杂志》2015年第4期439-446,共8页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(81372310;81100800)

摘　　要：血管化拟态(VM)是由具有可塑性的恶性肿瘤细胞构成的一种为肿瘤快速生长提供血供的血管样管道。经典信号通路、Notch/Nodal和低氧诱导因子(HIF)等多条信号通路参与调节构成VM细胞的可塑性,其关键蛋白也成为潜在的临床治疗靶点和诊断肿瘤细胞恶性度、侵袭、表型等的标志物。多种类型的肿瘤存在VM,并与肿瘤的病理级别及患者的预后有关。本文主要讨论VM起源、参与形成机制的信号通路和关键蛋白,以及针对VM的临床治疗进展。Vasculogenic mimicry（VM） refers to the plasticity of malignant tumor cells forming vessel networks to provide blood supply to perfusion of rapidly growing tumors. Key proteins associated with classical, stem cell, hypoxia-related and other multiple signaling pathways, which are involved in regulating functional plasticity of tumor cell VM, have become potential clinical therapeutic targets and diagnostic indicators of the aggressive, metastatic phenotype. VM has been observed in several tumor types and its occurrence is strongly associated with a poor prognosis. This review focuses on the origin and signal molecules and cascades involved in VM, and the clinical significance of VM regarding anti-angiogenesis treatment modalities.

关 键 词：肿瘤 血管化拟态 信号通路 血管生成 临床治疗 

分 类 号：R73-3[医药卫生—肿瘤]