脉冲释药微丸的研究进展  

Pulsatile delivery pellets:research advances

作　　者：冯航[1,2] 李迎[2] 梅兴国[2] 

机构地区：[1]武汉工程大学化工与制药学院,武汉430073 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《国际药学研究杂志》2015年第4期483-487,共5页Journal of International Pharmaceutical Research

摘　　要：机体正常生理功能的调节是由特定时间和特定部位瞬间释放的生物活性物质所控制的。脉冲释药系统是根据疾病的昼夜节律特点,并遵循时辰药理学原理在最佳时间释放药物,达到最佳疗效和最低毒副作用的一种释药模型。近几年,脉冲微丸以无剂量突释、可预测的胃排空时间、灵活的释药模式和较高的生物利用度的特点受到越来越多的关注。本文主要介绍脉冲微丸的设计原理及其研究进展。Under physiological conditions, many vital functions of the body are controlled by transient release of bioactive substances at a specific time and site. Based on the circadian rhythm character of disease and chronotherapeutic conceptions, pulsatile delivery system has been designed to achieve optimal therapeutic effect and reduce the toxic and side-effect. In recent years, more and more studies are focused on the pulsatile multiparticulate drug delivery system. Pulsatile multiparticulate system possesses many benefits, such as no risk of dose dumping, predictable gastric emptying, flexible release patterns and increased bioavailability. Based on these premises, the aim of this review is to summarize the major design methods of pulsatile multiparticulate and the research progress.

关 键 词：脉冲微丸 脉冲释药系统 时辰药理学 

分 类 号：R96[医药卫生—药理学]