早期应用加巴喷丁治疗老年带状疱疹神经痛的效果  

Effect of early application of Gabapentin in the treatment of senile herpes zoster neuralgia

作　　者：张晓荣[1,2] 陈文琦[1,2] 

机构地区：[1]南京医科大学附属南京医院 [2]南京市第一医院皮肤科,江苏南京210006

出　　处：《中国医药导报》2015年第26期4-7,19,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(81402619);江苏省科技发展计划项目(BK20130083)

摘　　要：目的：探讨早期应用加巴喷丁治疗老年带状疱疹神经痛的效果和安全性。方法选取南京医科大学附属南京医院皮肤科门诊2014年1月-2015年3月就诊的年龄≥60岁、视觉模拟（VAS）评分跃4分的急性期带状疱疹患者80例，根据随机数字表法分为治疗组和对照组，每组各40例。对照组常规予更昔洛韦抗病毒和甲钴胺营养神经治疗，治疗组在此基础上给予加巴喷丁，评价连续用药1、2、4周后疼痛的缓解情况及不良反应。结果治疗1周后，治疗组VAS评分[（5.53±0.21）分]较对照组[（6.92±0.23）分]明显下降，差异有统计学意义（P〈0.05）；治疗神经痛有效率（90.0%）高于对照组（70.0%），差异有统计学意义（P〈0.05）。治疗4周后，治疗组VAS评分[（2.20±0.11）分]明显低于对照组[（3.41±0.26）分]，差异有统计学意义（P〈0.05）；治疗神经痛有效率（100.0%）高于对照组（90.0%），差异有统计学意义（P〈0.05）。治疗组治疗带状疱疹的疼痛缓解时间、疼痛缓解程度明显优于对照组，差异有统计学意义（P〈0.05）；头晕、嗜睡等不良反应发生率高于对照组，差异有统计学意义（P〈0.05），但无其他严重不良反应。结论早期应用加巴喷丁对老年带状疱疹的神经痛有显著缓解作用，可能会降低后遗神经痛的发生率，且无严重不良反应，具有临床使用价值。Objective To observe the effect and safety of early application of Gabapentin in the treatment of senile herpes zoster neuralgia. Methods From January 2014 to March 2015, in Department of Dermatology, Nanjing Hospital Affiliated to Nanjing Medical University, 80 acute herpes zoster outpatients with ≥ 60 years old and visual analogue scales （VAS） 〉4 scores were selected. They were divided into two groups according to random number table, with 40 cases in each group. The control group was treated with conventional Ganciclovir and Mecobalamine, the treatment group was treated with Gabapentin based on conventional therapy. After continuous treatmnet 1, 2, 4 weeks, pain re-lief and adverse reaction of two groups were evaluated. Results After treatment 1 week, VAS of the treatment group [（5.53±0.21） scores] was significantly lower than that of the control group [（6.92±0.23） scores], the difference was sta-tistically significant （P〈 0.05）; and the effect rate of neuralgia treatment of the treatment group （90.0%） was higher than that of the control group （70.0%）, the difference was statistically significant （P〈 0.05）. After treatment 4 weeks, VAS of the treatment group [（2.20±0.11） scores] was significantly lower than that of the control group [（3.41±0.26） scores], the difference was statistically significant （P〈0.05）;and the effect rate of neuralgia treatment of the treatment group （100.0%） was higher than that of the control group （90.0%）, the difference was statistically significant （P〈0.05）. The time and degree of pain relief of the treatment group were significantly better than those of the control group, the differences were statistically significant （P 〈 0.05）. The incidence of adverse reactions such as dizziness and sleepi-ness in the treatment group was significantly higher than that in the control group, the difference was statistically signif-icant （P〈 0.05）, and no other significant adverse reactions occurred. Conclusion Early app

关 键 词：加巴喷丁 带状疱疹 神经痛 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]