中药与需要浓度监测的西药相互作用的物质基础及机制分析  

Analysis on Mechanisms and Material Basis of Interactions between Traditional Chinese Medicine and Therapeutic Concentration Monitoring Needed Drug

作　　者：李映辉[1] 徐婷[1] 

机构地区：[1]广东省中医院,广东广州510370

出　　处：《中医药导报》2015年第18期33-37,40,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广东省中医药管理局科研项目(20130601)

摘　　要：目的:探讨与治疗浓度监测西药相互作用的中药物质及机制,为临床合理、安全用药提供资料信息。方法:通过对2000-2014年国内外各大索引收录的中药与西药相互影响的研究文献进行梳理,分析中药物质及机制,并挖掘相似性质的中药提示可能存在的相互作用。结果:目前中药对治疗浓度监测西药影响研究结果主要有:(1)结论相对明确;(2)结论不一致,需进一步研究;(3)未提示两者存在相互影响。研究方式主要以动物实验为主的药代动力学方面的研究。结论不一致考虑与中药产地不同,受试人群或测试方法等方面相关。结论:目前研究方式主要以动物实验为主的药代动力学研究,为更科学合理地中西药联用,可通过临床试验进一步阐明。Objective： To study the material basis and mechanisms of interactions between traditional Chinese medicine and therapeutic concentration monitoring （TDM）-needed drug, then to provide references for rational use in clinic. Method： Literatures related to drug-herbal interaction were retrieved from the major domestic and foreign index from 2000 to 2014. Material basis and mechanism for traditional Chinese medicine were analyzed and the potential interactions were predicated. Results： The results of the current researches about the impact of herb on TDM-needed drug mainly were： （1）the conclusions were relatively clear; （2）the interaction between the two have not been prompted, and further research is needed; （3）there was no interaction between the two. The inconsistent conclusion may be caused by different origin or population or others related to test methods. Conclusions： Most of the researches were based on pharmacokinetic animal experiments. To use Chinese medicine and westem medicine seientificly and rationally, there are more clinical trials to be done.

关 键 词：治疗浓度监测西药 中药 相互作用 机制 

分 类 号：R285.5[医药卫生—中药学]