IL1B基因-31位点SNP与EV71手足口病的相关性研究  

The association between IL1B gene-31 single nucleotide polymorphism and HFMD with EV71 infection

作　　者：邹容容[1] 张国良[2] 刘映霞[1] 林益敏[1] 袁静[2] 李建明[2] 王艳荣[2] 邓永[1] 曾文[1] 周伯平[2] 

机构地区：[1]南华大学附属深圳市第三人民医院,广东518112 [2]深圳大学附属第三临床学院

出　　处：《中华实验和临床病毒学杂志》2015年第4期313-315,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：广东省医学科研基金（No.A2014519）;深圳市新发传染病重点专科基金（No.201161）;深圳市科技计划项目（JCYJ20140411112047888）

摘　　要：目的探讨IL1B基因-31位点单核苷酸多态性（SNP）与EV71手足口病（HFMD）易感性及临床表型的相关性。方法采用病例-对照研究方法，应用TaqMan探针基因分型技术，对1196例EV71HFMD[（其中801例为轻症（M—EV71），395例为重症（S-EV71）]和573例健康对照人群（HC）IL1B基因-31位点进行分型，比较两组人群等位基因频率差异。（1）探讨IL1B基因-31位点SNP与EV71HFMD易感性的相关性；（2）探讨在不同性别中-31位点SNP与EV71HFMD易感性的相关性；（3）探讨-31位点SNP与EV71HFMD临床表型的相关性。结果（1）EV71HFMD患者中IL1B基因-31T等位基因的频率明显高于HC，这提示T等位基因增加了患EV71HFMD的风险（OR=1．22；95％CI，1．06-1．40；P=0．007）；（2）男性EV71HFMD患者中IL1B基因-31T等位基因的频率明显高于男性HC，这提示T等位基因也增加了男性患EV71HFMD的风险（OR=1．24；95％CI，1．03-1．48；P=0．022）；（3）IL1B基因-31位点SNP与EV71HFMD的严重程度无相关性。结论IL1B基因-31T等位基因与EV71HFMD易感性相关，而与EV71HFMD严重程度无相关性；IL1B基因-31T等位基因与男性EV71HFMD的易感性也具有相关性。Objective To explore the association between IL-1B gene-31 single nucleotide polymorphisms （SNP） and susceptibility and severity of EV71 HFMD. Methods The genotype of IL-1B gene-31 SNP was determined in EV71 HFMD （n = 1196, including 801 mild cases, 395 severe cases）and healthy control group （HC, n = 573 ）with TaqMan assay in a case-control study. （1）To explore the association between-31 SNP and susceptibility to EV71 HFMD; （2）To explore the association between-31 SNP and susceptibility to EV71 HFMD in different sex population;（3）To explored the association between- 31 SNP and severity to EV71 HFMD. Results （1）IL-1B gene-31 T allele frequency was significantly higher in EV71 HFMD than that in HC. （2）IL-1B gene-31 T allele frequency was significantly higher in EV71 HFMD than in HC for male population. （3）The IL-1B gene-31 T is not associated with the severity of EV71 HFMD. Conclusion The IL-1B gene-31 T allele was associated with susceptibility to EV71 HFMD,but was not associated with the severity of EV71 HFMD,especially, the IL-1B gene-31 T allele was associated with susceptibility to EV71 HFMD for male population.

关 键 词：白细胞介素1 多态性 单核苷酸 手足口病 

分 类 号：R725.1[医药卫生—儿科]