风湿性心脏瓣膜病患者血清Ang(1-7)浓度与心房颤动的发生相关性分析  

The Correlation analysis between the serum concentration of ang(1-7)in the patients with rheumatic valvular heart disease and the occurrence of atrial fibrillation

作　　者：蒋永荣[1] 张殿新[2] 程功[3] 潘军强[3] 周鑫[1] 武金娥 孙超峰[1] 

机构地区：[1]西安交通大学第一附属医院心血管内科,西安710061 [2]第四军医大学西京医院心血管内科 [3]陕西省人民医院心脏内二科

出　　处：《陕西医学杂志》2015年第8期994-995,共2页Shaanxi Medical Journal

基　　金：中国医师协会房颤专项基金(2013-1-21)

摘　　要：目的:分析风湿性心脏瓣膜病患者血浆血管紧张素1-7(Ang1-7)的浓度与心房颤动发生之间的相关性,探讨Ang(1-7)在风湿性心脏瓣膜病房颤发生与维持中的作用及房颤的预防及治疗新的靶点。方法:收取风湿性心脏瓣膜病患者(AF组24例,SR组22例)外周静脉血,用ELISA法检测血清中Ang(1-7)、血管紧张素Ⅱ(AngⅡ)的浓度,分析两组间的差别及相关性。结果:在AF组,1左心房直径明显大于SR组(P<0.05);2血清Ang(1-7)浓度显著低于SR组(P<0.05);3血清AngⅡ浓度明显高于SR组(P<0.05)。结论:在风湿性心脏瓣膜病患者中,Ang(1-7)可能通过减弱AngⅡ的作用,抑制心房的重构,对于房颤的发生具有保护作用。Objective： By analysis of the correlation between the serum Ang（1-7） in the patients with rheumatic valvular heart disease and the occurrence of atrial fibrillation, to reveal the function of the Ang（1-7） in the occurrence and maintaining of atrial fibrillation and to find new targets for the prevention and treatment of atrial fibrillation. Methods： Collect the peripheral venous blood of the patients with rheumatic heart valve disease （total 46 patients, incude 24 with AF and 22 with SR）. Use ELISA method to detect the Ang （1-7）, Ang Ⅱ concentrations in the serum samples. Then, analysis the difference and correlation between the two groups, Results： In the AF group, ①the diameter of left atrium was significantly greater than the SR group（60.70±3.08＆48.15-2.16mm,P 〈0.05）②the serum concentration of Ang （1-7） was significantly lower than that in the SR group（146.05±17. 61 ＆321.71±f36.50 pg/ml,P〈0. 05） ③the serum concentration of Angll （45.88±2. 871＆35.78±1.08 pg/ml,P〈 0.05） were obviously higher than those in the SR group. Conclusion： For the patients with rheumatic valvular heart disease, the Ang （1-7） may weaken the function of Ang Ⅱ , and by this way inhibits the atrial remodeling, and has a protective effect on the occurrence of atrial fibrillation.

关 键 词：心脏瓣膜疾病 心房颤动 血管紧张素Ⅱ @Ang(1-7) 

分 类 号：R542.5[医药卫生—心血管疾病]