高原低氧影响药物代谢的研究进展  

A review of drug metabolism under hypoxia environment at high altitude

作　　者：张娟玲[1] 李向阳[2] 

机构地区：[1]青海大学生态环境工程学院,青海西宁810016 [2]青海大学医学院,青海西宁810001

出　　处：《药学学报》2015年第9期1073-1079,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81460568;30960457);教育部新世纪优秀人才支持计划资助项目(NCET-10-0917)

摘　　要：高原具有低氧、低压、强辐射、寒冷、干燥等环境特征,其中低氧是影响人体正常生命活动的主要因素,研究高原低氧条件下的药物代谢特征对于了解药物在高原机体的代谢和消除快慢,并指导高原地区临床合理用药具有重要意义。本文综述了高原低氧对药物代谢的影响,阐述了高原低氧条件下部分药物的代谢特征及药物代谢酶活性和表达的变化,并探讨了相关机制。The special environmental features of high altitude, such as hypobaric hypoxia, low temperature, arid, high solar radiation, variable climate and geochemical anomaly, cause great effects on human physiology and health. It will provide valuable references and new ideas to study drug＇smetabolism in special environment of high altitude hypoxia, and give the guidance to clinical reasonable medication, avoiding adverse reactions and personalized medicine in plateau areas. This article reviewed the effect of high altitude hypoxia on drug metabolism, elaborated metabolic characteristics of some drugs and the activity and expression of drug metabolism enzymes under hypoxia environment at high altitude, and discussed related mechanism.

关 键 词：高原 低氧 药物代谢动力学 药物代谢酶 

分 类 号：R969[医药卫生—药理学]