唑吡坦预防急性高原反应随机双盲安慰剂对照研究  

Oral zolpidem prevents acute mountain sickness: a randomized double-blind placebo controlled study

作　　者：黄永涛[1] 覃军[1] 高旭滨[1] 陈国柱[1] 郑程荣 杨杰[1] 黄岚[1] 

机构地区：[1]第三军医大学新桥医院心血管内科、全军心血管病研究所,重庆400037

出　　处：《解放军医学杂志》2015年第9期733-737,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国家卫生部卫生行业科研专项基金(201002012)~~

摘　　要：目的观察急性高原暴露后唑吡坦预防急性高原反应(AMS)的效果。方法采用高原现场随机双盲对照的研究方法,将40名受试者随机分为唑吡坦组与安慰剂组,分别在平原与高原采集一般资料、血压、心率、血氧饱和度、匹兹堡睡眠质量指数评分、AMS评分及体能测试结果。结果急性高原暴露后,唑吡坦组匹兹堡睡眠质量指数评分明显低于安慰剂组(P=0.047)。唑吡坦组6min步行距离明显大于安慰剂组(P=0.009)。不同时间点唑吡坦组AMS发病率均明显低于安慰剂组(P值分别为0.019、0.014、0.025、0.026),其中唑吡坦组各时间点的重度AMS发病率均低于安慰剂组(P值分别为0.047、0.044、0.031和0.020)。急性高原暴露20h后,唑吡坦组虚弱、疲劳、眩晕症状明显轻于安慰剂组(P<0.05)。急性高原暴露后两组心率、血压、氧饱和度、体力活动能力、左右手握力无明显差异(P>0.05)。结论唑吡坦能减轻AMS症状,降低AMS发病率,可望成为预防AMS的新选择。Objective To study the prophylactic effect of zolpidem on acute mountain sickness（AMS） after acute highaltitude exposure. Methods A randomized double-blind placebo controlled trial was performed on the plateau. Forty subjects were randomly divided into zolpidem group and placebo group. The general clinical data, heart rate, blood pressure, oxygen saturation, the Pittsburgh Sleep Quality Index（PSQI） scores, AMS scores and physical fitness test of the both groups were collected and assessed on plain and plateau, respectively. Results The PSQI scores were obviously lower and the six-minute walk distance was significantly longer in zolpidem group than those in placebo group（P=0.047 and P=0.009, respectively） after acute high-altitude exposure. AMS incidence was significantly lower in zolpidem group than in placebo group at different time points（P=0.019, 0.014, 0.025 and 0.026, respectively）, and the incidence of severe AMS was also significantly lower in zolpidem group than in placebo group at different time points（P=0.047, 0.044, 0.031 and 0.020, respectively）. The symptoms of dizziness, weakness and fatigue were significantly lighter in zolpidem group than in placebo group after acute exposure to high-altitude exposure for 20 hours（P〈0.05）. No significant difference was found in the general physiological findings including, heart rate, blood pressure, oxygen saturation, physical capacity, and the power of hand grip between the 2 groups after acute high-altitude exposure（P〉0.05）. Conclusion Zolpidem may alleviate AMS symptoms and reduce the incidence of AMS, so it may be promising as a new choice for the prevention of AMS.

关 键 词：唑吡坦 急性高原反应 高原 睡眠障碍 

分 类 号：R339.54[医药卫生—人体生理学] R186.4[医药卫生—基础医学]