降糖益津胶囊的急性毒性实验研究  

The acute toxicity test of JiangTangYiJin Capsules

作　　者：沈彦龙 赵岩[1] 徐殿文 郜玉钢[1] 蔡恩博[1] 刘双利[1] 杨鹤[1] 张连学[1] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118 [2]沈阳军区洮南训练场,吉林白城137100

出　　处：《时珍国医国药》2015年第8期1869-1871,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家科技支撑计划项目(No.2011BAI03B01);国家公益性行业科研专项(No.201303111);科技部科技人员服务企业项目(No.2009GJB10031);吉林省科技发展计划项(No.20130303094;No.20140204013YY;No.YYZX201258;No.20140311050YY)

摘　　要：目的评价降糖益津胶囊的急性毒性,测定其安全性,为临床用药提供依据。方法采用口服和腹腔注射两种方式对小鼠进行一次性给药,并观察7 d内小鼠的毒性反应及死亡情况。结果小鼠对该制剂的半数致死量(LD50)未测出,最大耐受量(MTD)为32g·kg-1。结论从药物的急性毒性作用来看,降糖益津胶囊的用药是安全的,因此具有很大的开发价值。Objective To evaluate acute toxicity of JiangTangYiJin Capsules and determine its safety,to provide the basis for clinical medication. Methods To observe the toxicity effect and death situation of mice in seven days by intraperitoneal injections and intragastric administration Jiang Tang Yi Jin Capsules,respectively. Results The LD50 of mice JiangTangYiJin Capsules unforeseen measured; MTD was 32g·kg^-1,respectively. Conclusion Looking at Jiang Tang Yi Jin capsule from the medicine toxic effect,the JiangTangYiJin Capsules is safe and non-toxic,which has tremendous development and utilization value.

关 键 词：降糖益津胶囊 半数致死量 最大耐受量 

分 类 号：R285.5[医药卫生—中药学]