幽门螺杆菌根除效果与中医证型临床研究  

Effect of Helicobacter Pylori Eradication and Traditional Chinese Medicine Syndrome Type of Clinical Research

作　　者：肖勇[1] 刘鹏[1] 李伟[1] 江立富[1] 王宁琴 

机构地区：[1]宁夏银川解放军第五医院,宁夏银川750004

出　　处：《辽宁中医药大学学报》2015年第9期158-161,共4页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:探讨胃舒乐加舒郁散联用雷贝拉唑根除Hp感染效果及中医证型疗效。方法:选择2011—2013年临床住院1640例Hp患者进行随机、单盲法分为治疗组和对照组。对照组:采用四联疗法口服阿莫西林胶囊0.5 g/次,3次/d;甲硝唑片0.4 g/次,3次/d;果胶铋胶囊3次/d,2粒/次。治疗组:采用三联疗法,冲服胃舒乐颗粒10 g/次,3次/d;舒郁散10 g/次,3次/d。两组均联用雷贝拉唑,口服,1次/晚,20 mg/次,时间为饭前1 h。2周为1个疗程。对两组内窥镜检查病变疗效及中医证型疗效和Hp根除率为指标,对两组疗效进行比较;以幽门螺杆菌(Hp)为检测指标,对两组治愈后Hp根除率进行比较。结果:两组内窥镜检查病变疗效比较,具有统计学意义(P<0.05)。不同中医证型疗效及Hp根除率:肝胃湿热证、肝气犯胃证,治疗组与对照组比较,差异显著,有统计学意义(P<0.01);胃络瘀血证、肝胃郁血证、脾胃虚寒证、胃阴亏虚证、寒热夹杂证治疗组与对照组比较,差异显著,有统计学意义(P<0.05)。结论:舒郁散加胃舒乐联合雷贝拉唑治疗(Hp)中医证型疗效和Hp根除率效果显著,未见明显不良反应。Objective：Explore Shuyu San and Weishule Granule combined rabeprazole azole Hp infection eradication effect and effect of Traditional Chinese Medicine syndrome types. Methods：Choose clinical hospital from 2011 to 2013,1640 cases of patients with Hp to a random,single blind method,divided into treatment group（the control group. Treatment group a blunt gastric Weishule Granule,three times a day,10 g each time,Shuyu San three times a day,each time 10 g;control group a blunt Shuyu San three times a day,each time 10 g;both groups combined rabeprazole,oral,1 time/night,20 mg/time,time for 1 h before a meal,for a period of treatment 4 weeks. Curative effect of two groups of endoscopic lesions and Traditional Chinese medicine syndrome types of efficacy and Hp eradicate rate as the index,compares two groups of curative effect;with helicobacter pylori（Hp）as testing indexes,the Hp eradicate rate to compare the two groups after cure. Results：Two groups of endoscopic lesions curative effect comparison,statistically significant（P〈0.05）. Different syndrome types of traditional Chinese medicine curative effect and Hp eradicate rate：liver stomach qi damp heat syndrome,liver stomach syndrome,the treatment group compared with control group,significant difference was statistically significant（P〈0.01）;gastric collaterals blood stasis,liver congestion syndrome,spleen and stomach deficiency cold syndrome,stomach yin deficiency syndrome,not the treatment group compared with control group,significant difference was statistically significant（P〈0.05）. Conclusion：Shuyu San and Weishule Granule joint rabeprazole azole curative effect of traditional Chinese medicine syndrome type and Hp eradicate rate effect is remarkable,no obvious adverse reactions.

关 键 词：幽门螺杆菌 舒郁散加胃舒乐联用雷贝拉唑 中医证型疗效 HP根除率 

分 类 号：R289.5[医药卫生—方剂学]