心血管疾病常用中药注射液及相关中药有效组分研究概况  

Survey of active components in commonly-used Chinese materia medica injections and related Chinese materia medica for cardiovascular disease

作　　者：王淳[1] 刘丽梅[1] 宋志前[1] 董运茁 杜智勇[1] 宁张弛 刘元艳[2] 刘振丽[1] 

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700 [2]北京中医药大学中药学院,北京100029

出　　处：《中草药》2015年第15期2315-2328,共14页Chinese Traditional and Herbal Drugs

基　　金：国家重大基础研究"973"课题(B518401)

摘　　要：查阅中国知网、万方数据知识服务平台和Pub Med等数据库(截至2014年9月1日)以及相关参考书目,对目前治疗心血管疾病最常用中药注射液及相关中药有效组分相关文献进行汇总。心血管疾病最常用中药注射液有参附注射液、参麦注射液、刺五加注射液、丹红注射液等15种注射液,3个处方源于经典方剂,其他源于临床或科研处方;处方组成药味均较少,单味占到60%,最多为3味药;主要针对心血瘀阻证;多具有保护缺血-再灌注损伤、抗血栓形成、抗氧化、扩张冠脉等药理作用。涉及最多的中药是丹参、红参、红花,有效组分类型主要有黄酮、皂苷、醌类等,为有效治疗心血管疾病提供依据。To summarize the active components in commonly-used Chinese materia medica（CMM） injections and related CMM for cardiovascular disease,and provide the reference for the effective treatment of cardiovascular disease.We searched CNKI,Wanfang Data,PubMedand,and the reference lists of identified articles（from initial to September 1,2014）,and reviewed the literature.The commonly-used CMM injections for cardiovascular disease involve 15 kinds of injection,including Shenfu Injection,Shenmai Injection,Ciwujia Injection,Danhong Injection,etc.Three prescriptions originated from classical prescriptions but others were from the result of clinical and research.The CMMs in these prescriptions were all less in number,single flavor accounted for 60%,the maximum was three herbs.These injections mainly aimed at heart blood stasis syndrome,with many pharmacological effects of protection on cerebral ischemia-reperfusion damage,anti-thrombosis,anti-oxidants,and expansion of coronary artery.The most commonly-used CMMs were Salvia Miltiorrhiza Radix,Ginseng Radix et Rhizoma Rubra,and Carthami Flos.The kinds of active components included flavonoid,saponin,quinones,etc.This article provides a basis for the effective treatment of cardiovascular disease.

关 键 词：心血管疾病 中药注射液 中药 有效组分 黄酮类 皂苷类 醌类 

分 类 号：R285.6[医药卫生—中药学]