滨州市老年人群肺痨耐药菌群分布及危险因素的logistic回归分析  

Elderly phthisis drug-resistant bacteria distribution in Binzhou and logistic regression analysis of risk factors

作　　者：王俊玲 张宏军 赵吉庆 

机构地区：[1]滨州市结核病防治院,256600

出　　处：《国际医药卫生导报》2015年第18期2808-2810,共3页International Medicine and Health Guidance News

摘　　要：目的对滨州市老年人群中患肺痨的临床资料进行回顾性分析，探讨老年肺痨患者耐药菌群分布情况及导致耐药菌感染的危险因素。方法回顾性分析263例老年肺痨患者的临床资料，对患者耐药菌感染率、耐药菌群分布及导致耐药菌感染的危险因素进行分析。结果所有患者中，共有51例患者为耐药菌感染，感染率为19．39％。仅1种药物耐药者构成比最高，占45．10％（患者23例），其次为耐2种及3种药物者，均为23．53％（患者均为12例），耐4种药物者构成比最低，仅占7．84％（患者4例），存在统计学差异。同时耐异烟肼药物者构成比最高，占27．27％（患者27例），其次为耐利福平药物者。占22．22％（患者22例），而耐水杨酸药物者构成比最低，仅为6．66％（患者6例）同样存在统计学差异。药物依从性、吸烟及糖尿病病史均为导致社区老年人群患肺痨的危险因素（P〈0．05），而性别、年龄、身高、体重、病程及高血压病史均非导致社区老年人群患肺痨的危险因素（P〉0．05）。结论社区老年肺痨患者的耐药菌感染发病率较高，且以单独一种药物耐药及耐异烟肼药物者居多，同时其发病与治疗中断、依从性差、吸烟及糖尿病病史密切相关，临床应注意以上因素。Objective To investigate elderly phthisidrug-resistanbacteridistribution in Binzhou and risk factors. MethodRetrospectively analyzed clinical datof 263 elderly phthisipatients. Drug-resistanbacteriinfection, drug-resistanbacteridistribution and risk factorof drug-resistanbacteriinfection were analyzed. ResultThere were 51 caseof drug-resistanbacteriinfection in all patients, with the infection rate of 19.39%. There waonly one kind of drug resistance in 23 case（45.10%）, two, three kindof drug resistance in 12 case（23.53%）, foukindof drug resistance in 4 case（7.84%）. 27 case（27.27%） were resistanto isoniazid, 22 case（22.22%） resistanto rifampicin, and 6 case（6.66%） resistanto salicyliacid. Drug compliance, the history of smoking and diabetewere risk factorof elderly phthisiin community （P〈0.05）, while gender, age, height, weight, duration and the history of high blood pressure were no（P〉0.05）. ConclusionThe incidence of elderly phthisidrug-resistanbacteriinfection in community ihigh, one kind of drug resistance and resistance to isoniazid are the moscommon. Elderly phthisidrug-resistanbacteriinfection iclosely related to interrupted treatment, bad compliance, the history of smoking and diabetes, which should be paid attention to.

关 键 词：老年人群 肺痨 耐药菌群 危险因素 

分 类 号：R395.2[哲学宗教—心理学]