冠心病患者纤溶活性功能的变化及其临床意义  

The changes of fibrinolytic function in patients with coronary heart disease and its clinical implications

作　　者：杨玲[1] 黄景文[1] 罗韶金[1] 薛世荣[1] 杨泽福[1] 潘伟[1] 

机构地区：[1]南方医科大学附属南海人民医院心内科,佛山528200

出　　处：《白求恩医学杂志》2015年第4期350-352,共3页Journal of Bethune Medical Science

摘　　要：目的观察冠心病患者组织型纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制物-1(PAI-1)水平的变化,探讨纤溶活性功能的变化及其临床意义。方法选择冠心病患者151例,其中稳定型心绞痛(SA)47例,不稳定型心绞痛(UA)50例,急性心肌梗死(AMI)54例。采用ELISA法测定血浆t-PA、PAI-1浓度,并计算PAI-1/t-PA比值(P/T比值),比较不同类型冠心病患者上述3个指标的均数。结果血浆t-PA浓度比较,UA组患者低于SA组(P<0.01);AMI组低于SA组(P<0.01)。血浆PAI-1浓度比较,UA组患者高于SA组(P<0.01);AMI组高于SA组(P<0.01)。血浆P/T比值比较,UA组患者高于SA组(P<0.01);AMI组高于SA组(P<0.01)。结论纤溶活性功能减低是急性冠脉综合征(ACS)的重要病理生理基础之一,监测纤溶活性功能可有助于ACS的预警报告和指导ACS的防治。Objectives To study changes of plasma tissue-type plasminogen iactivator and plasminogen activator inhibitor lev- els in patients with coronary heart disease and to investigate its clinical implications. Methods Patients with coronary heart disease （one hundred and ffty one） were selected. They were divided into stable angina pectoris group （n = 47 ）, unstable angina pectoris group （n =50）and acute myocardial infarction （n =54）. Plasma concentration of t-PA and PAI-1 were measured by emzyme-linked immu- nosorbent assay （ELISA）. Results Plasma concentrations of t-PA （ ng/ml ） ： UA group was lower significantly than SA group and （ P 〈 0. 01 ） ;AMI group was lower significantly than SA group （ P 〈 0. 01 ）. -Plasma concentration 8f PAI-1 （U/ml） ： UA group was higher significantly than SA group（ P 〈 0. 01 ） ;AMI group was higher significantly than SA group （ P 〈 0. 01 ） . PAI-1/t-PA ratios： UA group was higher significantly than SA group（ P 〈 0.0l ） ;AMI group was higher significantly than SA group （ P 〈 0.01 ）. Con- clusion Low fihrinolytic function is pathophysiological base of ACS, and to monitor fibrinolytic function is beneficial to early warning of ACS, and to guiding the prevent and treatment of ACS.

关 键 词：冠心病 组织型纤溶酶原激活物 纤溶酶原激活物抑制物-1 不稳定斑块 

分 类 号：R541.4[医药卫生—心血管疾病]